Interactor 1: LEU1 (P06208)
2-isopropylmalate synthase (EC 2.3.3.13) (Alpha-IPM synthase) (Alpha-isopropylmalate synthase)
Gene: LEU4
Interactor 2: LEU9 (Q12166)
2-isopropylmalate synthase 2, mitochondrial (EC 2.3.3.13) (Alpha-IPM synthase 2) (Alpha-isopropylmalate synthase 2) (Alpha-isopropylmalate synthase II)
Gene: LEU9
Species: Saccharomyces cerevisiae S288C
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.92 | 1.00 | 0.960 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25841022, 16429126, 16554755, 18719252, 37968396, 32051233, unassigned1933 |
| Identification Methods | protein complementation assay, affinity chromatography technology, two hybrid, cross-linking study, tandem affinity purification, dihydrofolate reductase reconstruction |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | HMGL-like~HMGL-like, LeuA_dimer~LeuA_dimer |
| Common GO terms | GO:0003852 - 2-isopropylmalate synthase activity GO:0005739 - mitochondrion GO:0008652 - amino acid biosynthetic process GO:0009098 - L-leucine biosynthetic process GO:0046872 - metal ion binding |
| Homologous interactions | 13 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
