HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: VAV3 (Q9UKW4)
Guanine nucleotide exchange factor VAV3 (VAV-3)
Gene: VAV3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11094073
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RhoGEF~fn3, SH2~fn3, C1_1~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 847
+	Hs
		411288 INSR_HUMAN (1-1382): 0: 1530: 100.00		VAV_HUMAN (1-846): 0: 609: 57.31
+	Hs
		435801 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		VAV3_HUMAN (1-847): 0: 663: 100.00
+	Hs
		435676 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		FGD5_HUMAN (1-614): 5.83e-77: 275: 13.26
+	Hs
		411292 INSR_HUMAN (1-1382): 0: 1530: 100.00		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		411352 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		435602 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		537729 INSRR_HUMAN (13-1341): 0: 1293: 51.12		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		855777 EPHA4_HUMAN (562-1354): 0: 565: 20.36		VAV2_HUMAN (1-846): 0: 574: 50.00
+	Hs
		279867 EPHA7_HUMAN (562-1356): 4.76e-172: 541: 19.48		TRIO_HUMAN (181-666): 3.3e-52: 201: 13.29
+	Hs
		562635 EPHA4_HUMAN (562-1354): 0: 565: 20.36		PLCG2_HUMAN (661-845): 3.61e-15: 82.4: 32.18
+	Hs
		580965 EPHA4_HUMAN (562-1354): 0: 565: 20.36		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		872610 EPHB1_HUMAN (571-1318): 0: 569: 21.86		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		580937 EPHB2_HUMAN (521-1316): 3.12e-175: 551: 20.21		PLCG1_HUMAN (661-845): 1.02e-14: 80.9: 30.35
+	Hs
		872630 EPHA4_HUMAN (562-1354): 0: 565: 20.36		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		872422 EPHA5_HUMAN (567-1319): 1.23e-176: 555: 20.98		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Mm
		872621 EPHB2_MOUSE (560-1316): 2.02e-176: 552: 20.35		GRB2_MOUSE (793-844): 2.65e-11: 65.9: 40.39
+	Hs
		665574 EPHB2_HUMAN (521-1316): 3.12e-175: 551: 20.21		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		665389 EPHA3_HUMAN (570-1319): 7.94e-174: 545: 20.56		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		924590 EPHA7_HUMAN (562-1356): 4.76e-172: 541: 19.48		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39
+	Hs
		665200 EPHA2_HUMAN (674-1320): 4.56e-172: 540: 21.91		GRB2_HUMAN (793-844): 2.55e-11: 65.9: 40.39