HitPredict

Interactor 1: SRC (P05480)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: RET (P35546)
Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
Gene: RET

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22732841
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Mm			1 1115
+	Hs
		463890 SRC_HUMAN (1-535): 0: 640: 98.69		RET_HUMAN (1-1115): 0: 1304: 83.15
+	Hs
		557090 SRC_HUMAN (1-535): 0: 640: 98.69		FGFR2_HUMAN (456-1066): 1.05e-160: 498: 32.16
+	Hs
		541302 SRC_HUMAN (1-535): 0: 640: 98.69		FGFR1_HUMAN (456-1062): 1.36e-155: 485: 31.42
+	Mm
		431334 SRC_MOUSE (1-535): 0: 648: 100.00		EPHB2_MOUSE (361-1074): 1.05e-149: 475: 20.00
+	Hs
		557120 SRC_HUMAN (1-535): 0: 640: 98.69		EPHA3_HUMAN (362-1041): 1.18e-149: 475: 20.49
+	Hs
		557121 SRC_HUMAN (1-535): 0: 640: 98.69		EPHB2_HUMAN (361-1074): 8.26e-149: 474: 20.14
+	Mm
		431341 SRC_MOUSE (1-535): 0: 648: 100.00		EGFR_MOUSE (429-1114): 9.18e-144: 465: 22.96
+	Hs
		557317 SRC_HUMAN (1-535): 0: 640: 98.69		ERBB4_HUMAN (418-1098): 1.78e-143: 466: 21.64
+	Hs
		557238 SRC_HUMAN (1-535): 0: 640: 98.69		ROR1_HUMAN (432-1109): 1.65e-146: 465: 20.82
+	Rn
		1455868 SRC_RAT (1-535): 0: 641: 99.44		Q9QX70_RAT (429-1114): 1.12e-141: 459: 22.04
+	Hs
		362677 SRC_HUMAN (1-535): 0: 640: 98.69		EGFR_HUMAN (430-1114): 7.76e-142: 460: 23.96
+	Hs
		362614 YES_HUMAN (1-535): 0: 608: 73.85		EGFR_HUMAN (430-1114): 7.76e-142: 460: 23.96
+	Rn
		1317361 SRC_RAT (1-535): 0: 641: 99.44		Q8K3F9_RAT (430-1114): 2.12e-123: 411: 23.56
+	Hs
		557143 SRC_HUMAN (1-535): 0: 640: 98.69		VGFR2_HUMAN (703-1044): 2.77e-78: 283: 41.27
+	Mm
		431316 SRC_MOUSE (1-535): 0: 648: 100.00		CSF1R_MOUSE (707-1019): 5.94e-75: 270: 39.67
+	Hs
		532036 SRC_HUMAN (1-535): 0: 640: 98.69		KIT_HUMAN (703-1025): 2.02e-75: 271: 39.84
+	Hs
		456128 SRC_HUMAN (1-535): 0: 640: 98.69		CSF1R_HUMAN (707-1019): 7.21e-75: 269: 40.77
+	Hs
		557144 SRC_HUMAN (1-535): 0: 640: 98.69		FLT3_HUMAN (707-1015): 5.54e-74: 267: 39.95
+	Hs
		462957 YES_HUMAN (1-535): 0: 608: 73.85		KIT_HUMAN (703-1025): 2.02e-75: 271: 39.84
+	Hs
		456122 YES_HUMAN (1-535): 0: 608: 73.85		CSF1R_HUMAN (707-1019): 7.21e-75: 269: 40.77