HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: SPTB2 (Q01082)
Spectrin beta chain, non-erythrocytic 1 (Beta-II spectrin) (Fodrin beta chain) (Spectrin, non-erythroid beta chain 1)
Gene: SPTBN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 2364
+	Hs
		433700 LYN_HUMAN (1-509): 0: 582: 62.72		SPTB2_HUMAN (1-2364): 0: 751: 100.00
+	Hs
		211480 SRC_HUMAN (20-507): 0: 586: 55.00		ACTN4_HUMAN (53-525): 6.51e-121: 409: 47.58
+	Hs
		521454 SRC_HUMAN (20-507): 0: 586: 55.00		ACTN1_HUMAN (28-775): 4.31e-92: 323: 34.25
+	Hs
		337296 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		SPTA1_HUMAN (179-1394): 3.14e-92: 337: 19.60
+	Hs
		360640 BTK_HUMAN (7-505): 1.49e-167: 490: 33.27		SPTA1_HUMAN (179-1394): 3.14e-92: 337: 19.60
+	Hs
		521527 BTK_HUMAN (7-505): 1.49e-167: 490: 33.27		ACTN1_HUMAN (28-775): 4.31e-92: 323: 34.25
+	Hs
		993249 PTK6_HUMAN (63-499): 1.36e-161: 467: 40.41		ACTN3_HUMAN (41-776): 4.93e-97: 338: 33.73
+	Hs
		411682 LCK_HUMAN (1-509): 0: 661: 100.00		DYST_HUMAN (537-1421): 8.42e-22: 106: 12.00
+	Hs
		411715 LCK_HUMAN (1-509): 0: 661: 100.00		SPTN1_HUMAN (152-1087): 9.93e-19: 96.3: 16.89
+	Hs
		411637 LCK_HUMAN (1-509): 0: 661: 100.00		UTRN_HUMAN (212-2073): 1e-17: 93.2: 10.02
+	Hs
		411889 LCK_HUMAN (1-509): 0: 661: 100.00		MACF1_HUMAN (687-1920): 4.98e-16: 87.6: 12.23
+	Hs
		297808 LYN_HUMAN (1-509): 0: 582: 62.72		K0754_HUMAN (210-1343): 2.52e-36: 154: 15.07
+	Hs
		164551 LCK_HUMAN (1-509): 0: 661: 100.00		SPTN2_HUMAN (1661-2338): 1.76e-11: 72.4: 15.10
+	Hs
		433710 LYN_HUMAN (1-509): 0: 582: 62.72		DYST_HUMAN (537-1421): 8.42e-22: 106: 12.00
+	Hs
		433543 LYN_HUMAN (1-509): 0: 582: 62.72		DMD_HUMAN (234-2093): 2.37e-21: 105: 9.67
+	Hs
		433753 LYN_HUMAN (1-509): 0: 582: 62.72		SPTN1_HUMAN (152-1087): 9.93e-19: 96.3: 16.89
+	Hs
		433640 LYN_HUMAN (1-509): 0: 582: 62.72		UTRN_HUMAN (212-2073): 1e-17: 93.2: 10.02
+	Hs
		434078 LYN_HUMAN (1-509): 0: 582: 62.72		MACF1_HUMAN (687-1920): 4.98e-16: 87.6: 12.23
+	Hs
		164555 LYN_HUMAN (1-509): 0: 582: 62.72		SPTN2_HUMAN (1661-2338): 1.76e-11: 72.4: 15.10
+	Hs
		337470 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		SPTN1_HUMAN (152-1087): 9.93e-19: 96.3: 16.89