HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: PHLB3 (Q6NSJ2)
Pleckstrin homology-like domain family B member 3
Gene: PHLDB3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	-
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 640
+	Hs
		433861 LYN_HUMAN (1-509): 0: 582: 62.72		PHLB2_HUMAN (44-636): 4.45e-74: 260: 25.87
+	Hs
		433874 LYN_HUMAN (1-509): 0: 582: 62.72		PKHH2_HUMAN (4-631): 8.28e-59: 216: 12.69
+	Hs
		412058 FYN_HUMAN (30-507): 0: 586: 59.01		MYH9_HUMAN (8-493): 2.61e-35: 145: 9.45
+	Hs
		433620 LYN_HUMAN (1-509): 0: 582: 62.72		MYH9_HUMAN (8-493): 2.61e-35: 145: 9.45
+	Hs
		111443 J3QRU1_HUMAN (26-507): 0: 581: 58.06		MYH9_HUMAN (8-493): 2.61e-35: 145: 9.45
+	Hs
		433272 YES_HUMAN (26-507): 0: 581: 58.06		MYH9_HUMAN (8-493): 2.61e-35: 145: 9.45
+	Hs
		411581 LCK_HUMAN (1-509): 0: 661: 100.00		DESP_HUMAN (66-484): 4.25e-09: 62: 13.26
+	Hs
		724720 BLK_HUMAN (1-509): 0: 557: 59.35		MYH9_HUMAN (8-493): 2.61e-35: 145: 9.45
+	Hs
		411983 FYN_HUMAN (30-507): 0: 586: 59.01		DESP_HUMAN (66-484): 4.25e-09: 62: 13.26
+	Hs
		433558 LYN_HUMAN (1-509): 0: 582: 62.72		DESP_HUMAN (66-484): 4.25e-09: 62: 13.26