HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: PTN5 (P54829)
Tyrosine-protein phosphatase non-receptor type 5 (EC 3.1.3.48) (Neural-specific protein-tyrosine phosphatase) (Striatum-enriched protein-tyrosine phosphatase) (STEP)
Gene: PTPN5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11983687
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 537 Hs			1 565
+	Mm
		763383 FYN_MOUSE (1-537): 0: 642: 99.44		PTN5_MOUSE (25-565): 0: 746: 90.02
+	Rn
		719284 FYN_RAT (1-537): 0: 641: 99.63		PTN5_RAT (197-565): 0: 519: 94.85
+	Rn
		139606 SRC_RAT (1-537): 0: 601: 67.72		PTPRR_RAT (128-565): 0: 545: 49.11
+	Hs
		412146 FYN_HUMAN (1-537): 0: 643: 100.00		PTN11_HUMAN (237-565): 1.01e-116: 360: 33.14
+	Mm
		574000 FYN_MOUSE (1-537): 0: 642: 99.44		PTPRA_MOUSE (111-564): 1.66e-114: 361: 24.64
+	Rn
		1144045 FYN_RAT (1-537): 0: 641: 99.63		Q66HJ7_RAT (111-564): 1.35e-114: 360: 24.64
+	Hs
		411997 FYN_HUMAN (1-537): 0: 643: 100.00		PTPRA_HUMAN (111-564): 9.05e-114: 358: 24.43
+	Hs
		522804 SRC_HUMAN (1-537): 0: 598: 68.21		PTN6_HUMAN (177-564): 3.89e-129: 392: 30.64
+	Hs
		412016 FYN_HUMAN (1-537): 0: 643: 100.00		PTPRD_HUMAN (296-561): 6.43e-104: 345: 35.90
+	Hs
		411959 FYN_HUMAN (1-537): 0: 643: 100.00		PTPRF_HUMAN (111-561): 9.47e-102: 339: 25.21
+	Mm
		56907 FYN_MOUSE (1-537): 0: 642: 99.44		PTPRF_MOUSE (111-561): 1.46e-101: 338: 24.21
+	Hs
		412017 FYN_HUMAN (1-537): 0: 643: 100.00		PTPRE_HUMAN (296-564): 2.83e-100: 320: 31.67
+	Rn
		1146020 SRC_RAT (1-537): 0: 601: 67.72		Q66HJ7_RAT (111-564): 1.35e-114: 360: 24.64
+	Mm
		403413 SRC_MOUSE (1-537): 0: 599: 68.33		PTPRA_MOUSE (111-564): 1.66e-114: 361: 24.64
+	Hs
		522756 SRC_HUMAN (1-537): 0: 598: 68.21		PTPRA_HUMAN (111-564): 9.05e-114: 358: 24.43
+	Rn
		976063 SRC_RAT (1-537): 0: 601: 67.72		PTPRA_RAT (111-564): 3.53e-110: 348: 24.22
+	Hs
		411950 FYN_HUMAN (1-537): 0: 643: 100.00		PTPRC_HUMAN (277-553): 1.51e-77: 268: 26.38
+	Rn
		94284 FYN_RAT (1-537): 0: 641: 99.63		F1LXJ9_RAT (296-559): 6.85e-67: 238: 27.27
+	Hs
		441169 SRC_HUMAN (1-537): 0: 598: 68.21		PTPRC_HUMAN (277-553): 1.51e-77: 268: 26.38
+	Hs
		412018 FYN_HUMAN (1-537): 0: 643: 100.00		PTPRZ_HUMAN (325-552): 1.81e-22: 104: 30.25