HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: DLG4 (P78352)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	12419528, 9892651
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, SH2~SH3_1, Guanylate_kin~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007612 - learning GO:0014069 - postsynaptic density GO:0031234 - extrinsic component of cytoplasmic side of plasma membrane and 1 others more... GO:0097110 - scaffold protein binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 537 Hs			1 724
+	Mm
		403445 SRC_MOUSE (1-537): 0: 599: 68.33		DLG4_MOUSE (1-724): 0: 667: 99.59
+	Hs
		522978 SRC_HUMAN (1-537): 0: 598: 68.21		MPP2_HUMAN (2-383): 6.03e-22: 102: 14.54
+	Rn
		73322 SRC_RAT (1-537): 0: 601: 67.72		PALS1_RAT (3-238): 3.33e-18: 90.9: 12.30
+	Hs
		411718 LCK_HUMAN (40-535): 0: 551: 57.60		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Mm
		411930 LCK_MOUSE (40-535): 0: 553: 57.20		DLG1_MOUSE (147-465): 2.02e-19: 95.5: 18.54
+	Hs
		433758 LYN_HUMAN (1-535): 0: 535: 54.48		SCRIB_HUMAN (58-243): 6.07e-25: 113: 40.72
+	Hs
		411698 LCK_HUMAN (40-535): 0: 551: 57.60		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		411753 LCK_HUMAN (40-535): 0: 551: 57.60		MPP7_HUMAN (8-289): 1.03e-19: 95.5: 12.50
+	Hs
		159139 HCK_HUMAN (1-535): 0: 548: 56.64		CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29
+	Hs
		411800 LCK_HUMAN (40-535): 0: 551: 57.60		DLG5_HUMAN (40-245): 4.76e-17: 88.2: 32.54
+	Hs
		433697 LYN_HUMAN (1-535): 0: 535: 54.48		EM55_HUMAN (2-325): 2.03e-22: 103: 14.41
+	Hs
		434043 LYN_HUMAN (1-535): 0: 535: 54.48		PALS2_HUMAN (2-203): 5.54e-21: 99.4: 14.42
+	Hs
		433731 LYN_HUMAN (1-535): 0: 535: 54.48		DLG1_HUMAN (147-465): 1.89e-19: 95.5: 17.93
+	Hs
		433812 LYN_HUMAN (1-535): 0: 535: 54.48		MPP7_HUMAN (8-289): 1.03e-19: 95.5: 12.50
+	Hs
		159138 LYN_HUMAN (1-535): 0: 535: 54.48		CSKP_HUMAN (6-200): 2.34e-19: 95.2: 14.29
+	Hs
		433909 LYN_HUMAN (1-535): 0: 535: 54.48		DLG5_HUMAN (40-245): 4.76e-17: 88.2: 32.54