HitPredict

Interactor 1: P53 (P04637)
Cellular tumor antigen p53 (Antigen NY-CO-13) (Phosphoprotein p53) (Tumor suppressor p53)
Gene: TP53

Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 0.60 0.769

The method score is based on:

Property Details
Experiments 1661671, 26789255, 37438558, 9688277, 8380895, 17131388, 9450543, 7708685, 7724550, 29263404, 31971989, 31492752, 35025136, 35045253, 10438818, 8393140, 8221889, 17121805, 31002735, 15371341 and 8 others

more...
Identification Methods pull down, affinity chromatography technology, enzymatic study, x-ray crystallography, two hybrid, surface plasmon resonance, two hybrid prey pooling approach, two hybrid array
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions 18

Homologous interactions

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 11Aug2025