HitPredict

Interactor 1: ITAV (P06756)
Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
Gene: ITGAV

Interactor 2: ITB8 (P26012)
Integrin beta-8
Gene: ITGB8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 1.00 0.814

The method score is based on:

Property Details
Experiments 27655131, 1918072, 30061598
Identification Methods affinity chromatography technology, coimmunoprecipitation, electron microscopy 3D single particle reconstruction
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains FG-GAP~Integrin_beta, EGF_2~Integrin_alpha2, Integrin_alpha2~Integrin_beta, Integrin_alpha2~PSI_integrin
Common GO terms GO:0001570 - vasculogenesis
GO:0005178 - integrin binding
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0007155 - cell adhesion
and 11 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1048
Hs

1 769
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024