HitPredict

Interactor 1: PCCA (P05165)
Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)
Gene: PCCA

Interactor 2: MCCA (Q96RQ3)
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial (MCCase subunit alpha) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (3-methylcrotonyl-CoA carboxylase biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha)
Gene: MCCC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.54 1.00 0.737

The method score is based on:

Property Details
Experiments 24981860, unassigned3799
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Biotin_carb_C~Biotin_carb_C, Biotin_carb_C~Biotin_carb_N, Biotin_carb_C~Biotin_lipoyl, Biotin_carb_C~CPSase_L_D2, Biotin_carb_N~Biotin_carb_N, Biotin_carb_N~Biotin_lipoyl, Biotin_carb_N~CPSase_L_D2, Biotin_lipoyl~Biotin_lipoyl, Biotin_lipoyl~CPSase_L_D2, CPSase_L_D2~CPSase_L_D2, Biotin_carb_C~PCC_BT
Common GO terms GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol
GO:0009374 - biotin binding
and 1 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 728
Hs

1 725
+ Mm
+ Hs
+ Mm
+ Hs
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+ Hs
+ Hs
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+ Hs
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+ Sc
+ Sc
+ Cj
+ Ec
+ Sc
+ Hs

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Last updated: 11Aug2025