HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: DCLK2 (Q8N568)
Serine/threonine-protein kinase DCLK2 (EC 2.7.11.1) (CaMK-like CREB regulatory kinase 2) (CL2) (CLICK-II) (CLICK2) (Doublecortin domain-containing protein 3B) (Doublecortin-like and CAM kinase-like 2) (Doublecortin-like kinase 2)
Gene: DCLK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22939624
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 766
+	Hs
		438350 HS90B_HUMAN (19-732): 0: 1059: 86.13		DCLK2_HUMAN (1-766): 0: 782: 100.00
+	Hs
		432386 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K2_HUMAN (9-651): 5.62e-145: 440: 18.69
+	Hs
		432200 HS90A_HUMAN (1-732): 0: 1087: 100.00		M3K3_HUMAN (17-650): 4.69e-140: 427: 16.67
+	Hs
		431804 HS90A_HUMAN (1-732): 0: 1087: 100.00		PAK1_HUMAN (149-652): 1.76e-137: 418: 21.81
+	Hs
		438643 HS90B_HUMAN (19-732): 0: 1059: 86.13		M3K2_HUMAN (9-651): 5.62e-145: 440: 18.69
+	Hs
		432166 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC1G_HUMAN (384-759): 1.59e-135: 410: 35.25
+	Hs
		431825 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC2B_HUMAN (388-757): 1.89e-131: 407: 33.50
+	Hs
		431826 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC2G_HUMAN (388-753): 7.49e-133: 407: 34.87
+	Hs
		431827 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC2D_HUMAN (388-698): 3.75e-133: 405: 37.46
+	Hs
		432373 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC2A_HUMAN (388-712): 8.55e-133: 403: 37.08
+	Hs
		438469 HS90B_HUMAN (19-732): 0: 1059: 86.13		M3K3_HUMAN (17-650): 4.69e-140: 427: 16.67
+	Hs
		438441 HS90B_HUMAN (19-732): 0: 1059: 86.13		KCC1G_HUMAN (384-759): 1.59e-135: 410: 35.25
+	Hs
		438146 HS90B_HUMAN (19-732): 0: 1059: 86.13		KCC2B_HUMAN (388-757): 1.89e-131: 407: 33.50
+	Hs
		438147 HS90B_HUMAN (19-732): 0: 1059: 86.13		KCC2G_HUMAN (388-753): 7.49e-133: 407: 34.87
+	Hs
		438148 HS90B_HUMAN (19-732): 0: 1059: 86.13		KCC2D_HUMAN (388-698): 3.75e-133: 405: 37.46
+	Hs
		438631 HS90B_HUMAN (19-732): 0: 1059: 86.13		KCC2A_HUMAN (388-712): 8.55e-133: 403: 37.08
+	Hs
		431898 HS90A_HUMAN (1-732): 0: 1087: 100.00		KCC4_HUMAN (385-674): 2.41e-62: 218: 41.10
+	Hs
		438210 HS90B_HUMAN (19-732): 0: 1059: 86.13		KCC4_HUMAN (385-674): 2.41e-62: 218: 41.10
+	Hs
		1083212 H90B3_HUMAN (19-732): 0: 728: 65.41		KCC4_HUMAN (385-674): 2.41e-62: 218: 41.10