HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: INSRR (P14616)
Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
Gene: INSRR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	33961781, 35384245, 22939624
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 1297
+	Hs
		431488 HS90A_HUMAN (1-724): 0: 1072: 85.25		INSRR_HUMAN (1-1297): 0: 1365: 100.00
+	Hs
		435497 HS90B_HUMAN (1-724): 0: 1086: 100.00		IGF1R_HUMAN (9-1265): 0: 1222: 55.39
+	Hs
		431438 HS90A_HUMAN (1-724): 0: 1072: 85.25		IGF1R_HUMAN (9-1265): 0: 1222: 55.39
+	Hs
		438028 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHB1_HUMAN (455-1277): 0: 616: 20.88
+	Hs
		438029 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA4_HUMAN (455-1279): 0: 609: 20.55
+	Hs
		437918 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA2_HUMAN (455-1282): 9.77e-179: 556: 21.20
+	Hs
		171281 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHB6_HUMAN (645-1291): 7.18e-161: 510: 23.91
+	Hs
		437892 HS90B_HUMAN (1-724): 0: 1086: 100.00		EPHA1_HUMAN (657-1279): 2.19e-159: 505: 23.51
+	Hs
		171280 HS90A_HUMAN (1-724): 0: 1072: 85.25		EPHB6_HUMAN (645-1291): 7.18e-161: 510: 23.91
+	Hs
		438619 HS90B_HUMAN (1-724): 0: 1086: 100.00		ALK_HUMAN (946-1247): 1.07e-70: 263: 43.46
+	Hs
		438213 HS90B_HUMAN (1-724): 0: 1086: 100.00		NTRK2_HUMAN (957-1253): 1.12e-67: 247: 42.43
+	Hs
		169160 HS90B_HUMAN (1-724): 0: 1086: 100.00		MUSK_HUMAN (973-1242): 8.31e-67: 245: 42.61
+	Hs
		384122 HS90B_HUMAN (1-724): 0: 1086: 100.00		NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91
+	Hs
		169159 HS90A_HUMAN (1-724): 0: 1072: 85.25		MUSK_HUMAN (973-1242): 8.31e-67: 245: 42.61
+	Hs
		438205 HS90B_HUMAN (1-724): 0: 1086: 100.00		NTRK3_HUMAN (957-1242): 2.05e-62: 231: 40.84
+	Hs
		384111 HS90A_HUMAN (1-724): 0: 1072: 85.25		NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91
+	Hs
		437838 HS90B_HUMAN (1-724): 0: 1086: 100.00		FGFR1_HUMAN (948-1294): 6.81e-59: 221: 35.90
+	Hs
		431472 HS90A_HUMAN (1-724): 0: 1072: 85.25		FGFR1_HUMAN (948-1294): 6.81e-59: 221: 35.90
+	Hs
		437893 HS90B_HUMAN (1-724): 0: 1086: 100.00		ERBB3_HUMAN (2-296): 3.16e-34: 145: 18.24
+	Hs
		438189 HS90B_HUMAN (1-724): 0: 1086: 100.00		ERBB4_HUMAN (342-482): 7.06e-15: 82.4: 19.73