HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: SRBP1 (P36956)
Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)]
Gene: SREBF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding and 1 others more... GO:0046983 - protein dimerization activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 1147
+	Hs
		431605 HS90A_HUMAN (1-724): 0: 1072: 85.25		SRBP1_HUMAN (1-1147): 0: 910: 100.00
+	Mm
		513684 HS90B_MOUSE (1-724): 0: 1089: 99.59		TFE3_MOUSE (134-438): 8.24e-28: 121: 19.30
+	Mm
		432435 HS90A_MOUSE (1-724): 0: 1068: 84.31		TFE3_MOUSE (134-438): 8.24e-28: 121: 19.30
+	Hs
		431504 HS90A_HUMAN (1-724): 0: 1072: 85.25		MUC1_HUMAN (13-542): 9.47e-18: 91.6: 10.38
+	Hs
		438364 HS90B_HUMAN (1-724): 0: 1086: 100.00		KMT2C_HUMAN (3-442): 7.45e-09: 62.7: 10.06
+	Mm
		435925 ENPL_MOUSE (3-724): 0: 920: 45.29		TFE3_MOUSE (134-438): 8.24e-28: 121: 19.30
+	Sc
		366285 HSP82_YEAST (12-724): 0: 927: 61.26		SEC31_YEAST (38-404): 9.07e-10: 65.3: 13.25
+	Sc
		543728 HSC82_YEAST (13-724): 0: 922: 60.22		SEC31_YEAST (38-404): 9.07e-10: 65.3: 13.25