HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: SSRP1 (Q08945)
FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160)
Gene: SSRP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	29721183
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box, HMG_box~HMG_box_2
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 709
+	Hs
		996845 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		CIC_HUMAN (424-708): 7.87e-39: 157: 16.49
+	Hs
		449542 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		SP100_HUMAN (486-629): 1.52e-24: 111: 28.86
+	Hs
		617247 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		SP100_HUMAN (486-629): 1.52e-24: 111: 28.86
+	Mm
		776235 TOX3_MOUSE (91-165): 4.63e-29: 115: 40.00		SOX6_MOUSE (449-708): 4.9e-33: 138: 13.19
+	Hs
		297488 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		TOX4_HUMAN (484-678): 7.24e-32: 133: 23.86
+	Hs
		297438 TOX4_HUMAN (91-163): 1.19e-27: 111: 38.36		TOX4_HUMAN (484-678): 7.24e-32: 133: 23.86
+	Hs
		617244 SP100_HUMAN (25-178): 1.23e-34: 131: 87.66		SP100_HUMAN (486-629): 1.52e-24: 111: 28.86
+	Hs
		727795 SOX7_HUMAN (65-181): 1.3e-28: 112: 19.66		SOX5_HUMAN (441-648): 2.62e-30: 129: 19.23
+	Hs
		817974 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		SOX2_HUMAN (516-636): 8.67e-30: 122: 22.31
+	Hs
		449550 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		HMGB2_HUMAN (540-698): 5.17e-15: 76.3: 23.53
+	Hs
		449498 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		HMGB1_HUMAN (543-634): 1e-14: 75.5: 34.04
+	Hs
		70541 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		HGB1A_HUMAN (543-634): 1.33e-11: 66.3: 31.92
+	Hs
		175740 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		HMGB3_HUMAN (551-696): 3.34e-11: 65.2: 22.58
+	Hs
		175750 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		HMGB3_HUMAN (551-696): 3.34e-11: 65.2: 22.58