HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: MCAF1 (Q6VMQ6)
Activating transcription factor 7-interacting protein 1 (ATF-interacting protein) (ATF-IP) (ATF7-interacting protein) (ATFa-associated modulator) (hAM) (MBD1-containing chromatin-associated factor 1) (P621)
Gene: ATF7IP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	32867128
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 1270
+	Hs
		1311936 SOX7_HUMAN (65-181): 1.3e-28: 112: 19.66		CHD7_HUMAN (650-1177): 7.42e-32: 138: 12.63
+	Hs
		818550 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		CHD7_HUMAN (650-1177): 7.42e-32: 138: 12.63
+	Hs
		1243837 SOX7_HUMAN (65-181): 1.3e-28: 112: 19.66		KMT2C_HUMAN (33-1231): 1.44e-27: 124: 9.99
+	Hs
		881831 SOX10_HUMAN (4-98): 1.86e-21: 93.2: 14.74		CHD7_HUMAN (650-1177): 7.42e-32: 138: 12.63
+	Hs
		818266 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		KMT2C_HUMAN (33-1231): 1.44e-27: 124: 9.99
+	Hs
		643394 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		ATX2_HUMAN (345-1187): 1.4e-12: 74.7: 10.18
+	Hs
		1332326 SOX17_HUMAN (10-90): 2.4e-12: 67.1: 19.75		CHD7_HUMAN (650-1177): 7.42e-32: 138: 12.63
+	Hs
		1300971 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		CHD7_HUMAN (650-1177): 7.42e-32: 138: 12.63
+	Hs
		617343 SP100_HUMAN (25-178): 1.23e-34: 131: 87.66		ATX2L_HUMAN (387-1040): 2.11e-09: 64.3: 9.63
+	Hs
		1243843 SOX17_HUMAN (10-90): 2.4e-12: 67.1: 19.75		KMT2C_HUMAN (33-1231): 1.44e-27: 124: 9.99
+	Hs
		152684 SOX7_HUMAN (65-181): 1.3e-28: 112: 19.66		KMT2D_HUMAN (774-1162): 2.66e-09: 64.2: 14.89
+	Ce
		136646 SSP1B_CAEEL (91-208): 5.6e-18: 83.7: 32.80		RPB1_CAEEL (665-983): 7.39e-18: 92.3: 13.76
+	Hs
		297532 TOX4_HUMAN (91-163): 1.19e-27: 111: 38.36		ATX2L_HUMAN (387-1040): 2.11e-09: 64.3: 9.63
+	Hs
		817913 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		MAP1A_HUMAN (289-1199): 1.96e-10: 67.8: 7.83
+	Hs
		818301 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		ATX2L_HUMAN (387-1040): 2.11e-09: 64.3: 9.63
+	Hs
		152610 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		KMT2D_HUMAN (774-1162): 2.66e-09: 64.2: 14.89
+	Hs
		1296385 HM20B_HUMAN (64-165): 1.22e-15: 76: 32.35		ASPP1_HUMAN (717-1147): 6.14e-15: 82.3: 14.77
+	Hs
		152619 SOX10_HUMAN (4-98): 1.86e-21: 93.2: 14.74		KMT2D_HUMAN (774-1162): 2.66e-09: 64.2: 14.89
+	Hs
		867119 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		SC24C_HUMAN (817-1228): 8.01e-12: 72.2: 12.89
+	Hs
		152690 SOX17_HUMAN (10-90): 2.4e-12: 67.1: 19.75		KMT2D_HUMAN (774-1162): 2.66e-09: 64.2: 14.89