HitPredict

Interactor 1: TOM70 (P07213)
Mitochondrial import receptor subunit TOM70 (70 kDa mitochondrial outer membrane protein) (Translocase of outer membrane 70 kDa subunit)
Gene: TOM70

Interactor 2: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37295430
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~TPR_1, HSP90~TPR_8
Common GO terms	GO:0005739 - mitochondrion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 617 Sc			1 705
+	Sc
		392005 TOM70_YEAST (1-617): 4.91e-94: 303: 100.00		HSP82_YEAST (1-705): 0: 963: 95.63
+	Sc
		579349 TOM71_YEAST (4-617): 9.72e-83: 274: 48.06		HSC82_YEAST (1-705): 0: 971: 100.00
+	Sc
		392702 TOM71_YEAST (4-617): 9.72e-83: 274: 48.06		HSP82_YEAST (1-705): 0: 963: 95.63
+	Hs
		317976 TOM70_HUMAN (13-597): 1.52e-60: 214: 22.89		HS90B_HUMAN (5-705): 0: 1016: 61.15
+	Hs
		317975 TOM70_HUMAN (13-597): 1.52e-60: 214: 22.89		HS90A_HUMAN (4-705): 0: 1007: 60.67
+	Hs
		461421 IFT88_HUMAN (34-610): 2.97e-46: 177: 10.45		HS90A_HUMAN (4-705): 0: 1007: 60.67
+	Mm
		547256 PPP5_MOUSE (85-267): 3.03e-39: 152: 22.87		HS90B_MOUSE (5-705): 0: 1019: 61.57
+	Hs
		468210 PPP5_HUMAN (86-204): 4.91e-38: 149: 32.23		HS90B_HUMAN (5-705): 0: 1016: 61.15
+	Mm
		462116 PPP5_MOUSE (85-267): 3.03e-39: 152: 22.87		HS90A_MOUSE (4-705): 0: 1005: 60.59
+	Hs
		117618 PPP5_HUMAN (86-204): 4.91e-38: 149: 32.23		K9JA46_HUMAN (4-705): 0: 1007: 60.67
+	Hs
		461300 PPP5_HUMAN (86-204): 4.91e-38: 149: 32.23		HS90A_HUMAN (4-705): 0: 1007: 60.67
+	Hs
		468409 TOM34_HUMAN (68-192): 1.23e-21: 98: 25.40		HS90B_HUMAN (5-705): 0: 1016: 61.15
+	Hs
		461515 TOM34_HUMAN (68-192): 1.23e-21: 98: 25.40		HS90A_HUMAN (4-705): 0: 1007: 60.67
+	Hs
		468113 STIP1_HUMAN (40-526): 1.56e-17: 88.2: 9.23		HS90B_HUMAN (5-705): 0: 1016: 61.15
+	At
		690692 OE64C_ARATH (71-214): 5.08e-26: 114: 29.45		HS901_ARATH (3-705): 0: 987: 63.26
+	At
		146182 OE64C_ARATH (71-214): 5.08e-26: 114: 29.45		HS904_ARATH (3-705): 0: 984: 62.38
+	Hs
		117617 STIP1_HUMAN (40-526): 1.56e-17: 88.2: 9.23		K9JA46_HUMAN (4-705): 0: 1007: 60.67
+	Hs
		461192 STIP1_HUMAN (40-526): 1.56e-17: 88.2: 9.23		HS90A_HUMAN (4-705): 0: 1007: 60.67
+	At
		938321 OE64C_ARATH (71-214): 5.08e-26: 114: 29.45		HS902_ARATH (3-705): 0: 977: 63.93
+	Mm
		465815 PPP5_MOUSE (85-267): 3.03e-39: 152: 22.87		ENPL_MOUSE (3-705): 0: 891: 46.03