HitPredict

Interactor 1: PROS (P07225)
Vitamin K-dependent protein S
Gene: PROS1

Interactor 2: PRG2 (P13727)
Bone marrow proteoglycan (BMPG) (Proteoglycan 2) [Cleaved into: Eosinophil granule major basic protein (EMBP) (MBP) (Pregnancy-associated major basic protein)]
Gene: PRG2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 676 Hs			1 222
+	Hs
		452119 PROS_HUMAN (1-676): 1.8e-132: 407: 100.00		PRG3_HUMAN (12-222): 1.53e-53: 173: 49.30
+	Hs
		407813 SHBG_HUMAN (313-667): 8.9e-51: 183: 23.81		CLC4G_HUMAN (38-221): 9.2e-39: 137: 18.62
+	Hs
		1022269 FBLN2_HUMAN (94-251): 1.92e-24: 111: 30.00		PGCB_HUMAN (10-221): 6.77e-53: 184: 17.20
+	Hs
		317595 SLIT2_HUMAN (190-674): 7.48e-24: 109: 11.09		PRG3_HUMAN (12-222): 1.53e-53: 173: 49.30
+	Hs
		565099 FBLN2_HUMAN (94-251): 1.92e-24: 111: 30.00		CSPG2_HUMAN (4-221): 1.68e-45: 163: 17.00
+	Hs
		567860 GAS6_HUMAN (3-163): 1.02e-17: 89.2: 15.53		PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00
+	Hs
		567999 CELR1_HUMAN (2-169): 1.79e-13: 76.5: 15.61		PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00
+	Hs
		567974 CNTP3_HUMAN (233-675): 3.21e-13: 75.3: 12.58		PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00
+	Hs
		183290 LAMA5_HUMAN (59-338): 1.46e-11: 70.4: 12.57		PGCB_HUMAN (10-221): 6.77e-53: 184: 17.20
+	Hs
		183222 LAMA5_HUMAN (59-338): 1.46e-11: 70.4: 12.57		PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00
+	Hs
		567993 LTBP3_HUMAN (119-267): 1.69e-11: 69.7: 33.94		PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00
+	Hs
		567916 LTBP4_HUMAN (157-261): 6.39e-10: 65: 25.71		PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00
+	Hs
		565088 FBN1_HUMAN (87-288): 3.73e-14: 78.6: 23.01		CSPG2_HUMAN (4-221): 1.68e-45: 163: 17.00
+	Hs
		567807 FBN2_HUMAN (134-232): 9.87e-09: 61.2: 36.89		PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00
+	Hs
		567989 CELR2_HUMAN (9-120): 9.05e-09: 61.1: 8.66		PRG2_HUMAN (1-222): 1.94e-56: 180: 100.00
+	Hs
		772351 FBN2_HUMAN (134-232): 9.87e-09: 61.2: 36.89		PRG3_HUMAN (12-222): 1.53e-53: 173: 49.30