Protein: PROS
Vitamin K-dependent protein S

Gene: PROS, PROS1
Organism: Homo sapiens
Interactions: 66
UniProt ID: P07225

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004866 - endopeptidase inhibitor activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

452081

C4BPB
C4b-binding protein beta chain

4

6

Small-scale

0.899

High

268910

FCG3B
Low affinity immunoglobulin gamma Fc region receptor III-B

1

20

High-throughput

0.691

High

327023

NXPH3
Neurexophilin-3

1

8

High-throughput

0.691

High

402468

PROC
Vitamin K-dependent protein C

1

18

High-throughput

0.691

High

452114

SIRPD
Signal-regulatory protein delta

1

5

High-throughput

0.691

High

452101

ZPBP2
Zona pellucida-binding protein 2

3

0

High-throughput

0.638

High

452102

LYZL2
Lysozyme-like protein 2

2

4

High-throughput

0.628

High

452076

FA5
Coagulation factor V

2

11

Small-scale

0.602

High

452074

PAEP
Glycodelin

2

3

High-throughput

0.601

High

437618

HEPS
Serine protease hepsin

1

17

High-throughput

0.575

High

452083

I12R1
Interleukin-12 receptor subunit beta-1

1

6

High-throughput

0.575

High

452091

NOTC2
Neurogenic locus notch homolog protein 2

1

20

High-throughput

0.575

High

452113

TMPSD
Transmembrane protease serine 13

1

20

High-throughput

0.575

High

452111

TECT2
Tectonic-2

2

1

High-throughput

0.574

High

407747

VWF
von Willebrand factor

1

6

Small-scale

0.561

High

231033

VEGFD
Vascular endothelial growth factor D

1

4

High-throughput

0.536

High

341277

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.536

High

342486

LY86
Lymphocyte antigen 86

1

7

High-throughput

0.536

High

416586

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

2

High-throughput

0.536

High

452075

CFC1
Cryptic protein

1

6

High-throughput

0.536

High

452077

BMP4
Bone morphogenetic protein 4

1

14

High-throughput

0.536

High

452078

PRG2
Bone marrow proteoglycan

1

16

High-throughput

0.536

High

452079

EDN3
Endothelin-3

1

4

High-throughput

0.536

High

452082

WNT5A
Protein Wnt-5a

1

13

High-throughput

0.536

High

452084

TFPI2
Tissue factor pathway inhibitor 2

1

6

High-throughput

0.536

High

452085

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

3

High-throughput

0.536

High

452090

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

1

High-throughput

0.536

High

452094

ADIPO
Adiponectin

1

20

High-throughput

0.536

High

452096

DB136
Defensin beta 136

1

1

High-throughput

0.536

High

452097

GRPL2
GLIPR1-like protein 2

1

4

High-throughput

0.536

High

452100

LYZL1
Lysozyme-like protein 1

1

4

High-throughput

0.536

High

452109

ESPB1
Epididymal sperm-binding protein 1

1

13

High-throughput

0.536

High

452112

LCFC1
Sperm-egg fusion protein LLCFC1

1

7

High-throughput

0.536

High

452115

CST11
Cystatin-11

1

9

High-throughput

0.536

High

452080

KPCA
Protein kinase C alpha type

1

4

High-throughput

0.515

High

452087

1433G
14-3-3 protein gamma

1

5

High-throughput

0.515

High

452089

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

4

High-throughput

0.515

High

452110

OPTN
Optineurin

1

9

High-throughput

0.515

High

361567

FA8
Coagulation factor VIII

1

9

Small-scale

0.501

High

452116

SDF2L
Stromal cell-derived factor 2-like protein 1

1

9

High-throughput

0.489

High

452073

RSSA
Small ribosomal subunit protein uS2

1

1

High-throughput

0.481

High

217721

TGON2
Trans-Golgi network integral membrane protein 2

1

20

High-throughput

0.479

High

452093

SETB1
Histone-lysine N-methyltransferase SETDB1

1

4

High-throughput

0.470

High

452098

Q5SUL5
HLA class I histocompatibility antigen A alpha chain

1

2

High-throughput

0.470

High

73761

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

20

High-throughput

0.445

High

143724

WN10B
Protein Wnt-10b

1

13

High-throughput

0.445

High

167431

WNT9A
Protein Wnt-9a

1

13

High-throughput

0.445

High

170620

CLGN
Calmegin

1

8

High-throughput

0.445

High

183998

S22A1
Solute carrier family 22 member 1

1

3

High-throughput

0.445

High

388599

C1QA
Complement C1q subcomponent subunit A

1

20

High-throughput

0.445

High

452086

MFAP4
Microfibril-associated glycoprotein 4

1

10

High-throughput

0.445

High

452088

LCN6
Epididymal-specific lipocalin-6

1

5

High-throughput

0.445

High

452099

BRID5
BRICHOS domain-containing protein 5

1

2

High-throughput

0.445

High

452103

LYPD1
Ly6/PLAUR domain-containing protein 1

1

3

High-throughput

0.445

High

452106

PATE1
Prostate and testis expressed protein 1

1

5

High-throughput

0.445

High

452108

T106A
Transmembrane protein 106A

1

6

High-throughput

0.445

High

452119

PRG3
Proteoglycan 3

1

15

High-throughput

0.445

High

452118

TBK1
Serine/threonine-protein kinase TBK1

1

3

High-throughput

0.439

High

277255

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.437

High

446553

NPM
Nucleophosmin

1

4

High-throughput

0.437

High

452095

E2F4
Transcription factor E2F4

1

1

High-throughput

0.437

High

452117

FBX6
F-box only protein 6

1

20

High-throughput

0.437

High

452092

SLC31
Amino acid transporter heavy chain SLC3A1

1

0

High-throughput

0.426

High

452105

ITLN2
Intelectin-2

1

0

High-throughput

0.426

High

452104

LMO3
LIM domain only protein 3

1

0

High-throughput

0.268

Low

452107

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025