Protein: SHBG
Sex hormone-binding globulin (SHBG) (Sex steroid-binding protein) (SBP) (Testis-specific androgen-binding protein) (ABP) (Testosterone-estradiol-binding globulin) (TeBG) (Testosterone-estrogen-binding globulin)

Gene: SHBG
Organism: Homo sapiens
Interactions: 59
UniProt ID: P04278

Gene Ontology (top 5):
GO:0005496 - steroid binding
GO:0005497 - androgen binding
GO:0005576 - extracellular region
GO:0070062 - extracellular exosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

407775

SHBG
Sex hormone-binding globulin

1

9

Small-scale

0.621

High

407800

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.536

High

407816

CNT3B
Contactin-associated protein-like 3B

1

12

High-throughput

0.514

High

299021

FLOT1
Flotillin-1

1

2

Small-scale

0.481

High

369578

A2MG
Alpha-2-macroglobulin

1

1

Small-scale

0.481

High

407777

APOD
Apolipoprotein D

1

2

Small-scale

0.481

High

407779

CO1A2
Collagen alpha-2(I) chain

1

3

Small-scale

0.481

High

407783

ACPH
Acylamino-acid-releasing enzyme

1

1

Small-scale

0.481

High

407784

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.481

High

407788

DESM
Desmin

1

2

Small-scale

0.481

High

407789

FLNA
Filamin-A

1

7

Small-scale

0.481

High

407790

ZA2G
Zinc-alpha-2-glycoprotein

1

5

Small-scale

0.481

High

407791

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

1

Small-scale

0.481

High

407793

PTGDS
Prostaglandin-H2 D-isomerase

1

5

Small-scale

0.481

High

407797

ACTB
Actin, cytoplasmic 1

1

3

Small-scale

0.481

High

407799

ACTA
Actin, aortic smooth muscle

1

3

Small-scale

0.481

High

407801

GRB2
Growth factor receptor-bound protein 2

1

10

High-throughput

0.481

High

407802

ACTH
Actin, gamma-enteric smooth muscle

1

3

Small-scale

0.481

High

407803

EF1A1
Elongation factor 1-alpha 1

1

2

Small-scale

0.481

High

407820

TINAL
Tubulointerstitial nephritis antigen-like

1

1

Small-scale

0.481

High

407822

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

1

Small-scale

0.481

High

407823

KLK4
Kallikrein-4

1

12

Small-scale

0.481

High

407778

CATD
Cathepsin D

1

0

Small-scale

0.460

High

407785

ALDR
Aldo-keto reductase family 1 member B1

1

0

Small-scale

0.460

High

407786

PPAP
Prostatic acid phosphatase

1

0

Small-scale

0.460

High

407792

SORCN
Sorcin

1

0

Small-scale

0.460

High

407795

KAD2
Adenylate kinase 2, mitochondrial

1

0

Small-scale

0.460

High

407796

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

Small-scale

0.460

High

407798

DEST
Destrin

1

0

Small-scale

0.460

High

407804

DHSO
Sorbitol dehydrogenase

1

0

Small-scale

0.460

High

407814

CD177
CD177 antigen

1

0

Small-scale

0.460

High

407787

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.458

High

193082

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

3

Small-scale

0.439

High

220729

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

1

Small-scale

0.439

High

229200

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

1

Small-scale

0.439

High

344598

AP2A1
AP-2 complex subunit alpha-1

1

3

Small-scale

0.439

High

391683

MT2
Metallothionein-2

1

3

Small-scale

0.439

High

407776

MT1F
Metallothionein-1F

1

3

Small-scale

0.439

High

407780

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

Small-scale

0.439

High

407782

MT1G
Metallothionein-1G

1

3

Small-scale

0.439

High

407794

PA24A
Cytosolic phospholipase A2

1

1

Small-scale

0.439

High

407806

UBE3A
Ubiquitin-protein ligase E3A

1

2

Small-scale

0.439

High

407807

AP1B1
AP-1 complex subunit beta-1

1

2

Small-scale

0.439

High

407808

SEM3F
Semaphorin-3F

1

5

Small-scale

0.439

High

407809

MAD4
Max dimerization protein 4

1

3

Small-scale

0.439

High

407813

CLC4G
C-type lectin domain family 4 member G

1

5

High-throughput

0.439

High

407819

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

Small-scale

0.439

High

407812

TM236
Transmembrane protein 236

2

0

High-throughput

0.313

High

154455

CLD4
Claudin-4

1

0

Small-scale

0.251

Low

276938

MPU1
Mannose-P-dolichol utilization defect 1 protein

1

0

Small-scale

0.251

Low

407781

SRF
Serum response factor

1

0

Small-scale

0.251

Low

407805

PLP2
Proteolipid protein 2

1

0

Small-scale

0.251

Low

407810

NOMO1
BOS complex subunit NOMO1

1

0

Small-scale

0.251

Low

407811

HYI
Putative hydroxypyruvate isomerase

1

0

Small-scale

0.251

Low

407815

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

0

Small-scale

0.251

Low

407817

UIF
UAP56-interacting factor

1

0

Small-scale

0.251

Low

407818

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

Small-scale

0.251

Low

407821

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

Small-scale

0.251

Low


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Last updated: 11Aug2025