HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: PPARG (P37231)
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
Gene: PPARG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20195357
Identification Methods	display technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Hormone_recep
Common GO terms	GO:0001890 - placenta development GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0042277 - peptide binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 505
+	Hs
		461226 HS90A_HUMAN (1-724): 0: 1069: 85.25		PPARG_HUMAN (1-505): 2.48e-165: 479: 100.00
+	Hs
		468284 HS90B_HUMAN (1-724): 0: 1083: 100.00		PPARD_HUMAN (99-505): 1.48e-115: 349: 60.29
+	Hs
		461398 HS90A_HUMAN (1-724): 0: 1069: 85.25		PPARA_HUMAN (31-505): 4.23e-120: 362: 54.18
+	Hs
		395346 HS90B_HUMAN (1-724): 0: 1083: 100.00		ESR1_HUMAN (1-501): 9.13e-112: 345: 19.28
+	Hs
		461380 HS90A_HUMAN (1-724): 0: 1069: 85.25		PPARD_HUMAN (99-505): 1.48e-115: 349: 60.29
+	Hs
		395339 HS90A_HUMAN (1-724): 0: 1069: 85.25		ESR1_HUMAN (1-501): 9.13e-112: 345: 19.28
+	Hs
		468006 HS90B_HUMAN (1-724): 0: 1083: 100.00		VDR_HUMAN (139-503): 4.57e-108: 330: 26.68
+	Hs
		282917 HS90B_HUMAN (1-724): 0: 1083: 100.00		NR1I2_HUMAN (139-501): 1.19e-104: 321: 26.26
+	Hs
		343210 HS90B_HUMAN (1-724): 0: 1083: 100.00		ERR2_HUMAN (25-502): 1.06e-104: 321: 19.14
+	Hs
		468322 HS90B_HUMAN (1-724): 0: 1083: 100.00		NR1H3_HUMAN (52-501): 2.03e-104: 321: 24.78
+	Mm
		443608 HS90B_MOUSE (1-724): 0: 1086: 99.59		GCR_MOUSE (14-503): 2.05e-97: 313: 19.48
+	Hs
		403750 HS90B_HUMAN (1-724): 0: 1083: 100.00		GCR_HUMAN (18-503): 2e-98: 315: 17.85
+	Hs
		468077 HS90B_HUMAN (1-724): 0: 1083: 100.00		NR4A1_HUMAN (4-503): 3.34e-99: 312: 20.83
+	Hs
		282916 HS90A_HUMAN (1-724): 0: 1069: 85.25		NR1I2_HUMAN (139-501): 1.19e-104: 321: 26.26
+	Hs
		343207 HS90A_HUMAN (1-724): 0: 1069: 85.25		ERR2_HUMAN (25-502): 1.06e-104: 321: 19.14
+	Hs
		461425 HS90A_HUMAN (1-724): 0: 1069: 85.25		NR1H3_HUMAN (52-501): 2.03e-104: 321: 24.78
+	Hs
		403743 HS90A_HUMAN (1-724): 0: 1069: 85.25		GCR_HUMAN (18-503): 2e-98: 315: 17.85
+	Hs
		461775 HS90A_HUMAN (1-724): 0: 1069: 85.25		ESR2_HUMAN (23-502): 1.8e-98: 308: 18.70
+	Hs
		395422 ENPL_HUMAN (3-693): 0: 914: 46.44		ESR1_HUMAN (1-501): 9.13e-112: 345: 19.28
+	Hs
		403790 ENPL_HUMAN (3-693): 0: 914: 46.44		GCR_HUMAN (18-503): 2e-98: 315: 17.85