Interactor 1: MMP2 (P08253)
72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) (TBE-1) [Cleaved into: PEX]
Gene: MMP2
Interactor 2: TIMP2 (P16035)
Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)
Gene: TIMP2
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.95 | 1.00 | 0.977 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28514442, 12032297, 9410885, 33961781, 12374789, 10991943, 9182583, 39238192, 12023034, 19010413, 21839835 |
| Identification Methods | affinity chromatography technology, x-ray crystallography, biochemical, pull down, two hybrid, proximity labelling technology, surface plasmon resonance, protease assay, anti tag coimmunoprecipitation |
| Interaction Type | physical association, association, direct interaction, enzymatic reaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Hemopexin~TIMP, Peptidase_M10~TIMP |
| Common GO terms | GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0008270 - zinc ion binding |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
