Protein: MMP14
Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)

Gene: MMP14
Organism: Homo sapiens
Interactions: 78
UniProt ID: P50281

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001525 - angiogenesis
GO:0001541 - ovarian follicle development
GO:0001666 - response to hypoxia
GO:0001935 - endothelial cell proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

590837

TIMP2
Metalloproteinase inhibitor 2

7

20

Small-scale

0.963

High

370008

TIMP1
Metalloproteinase inhibitor 1

3

20

Small-scale

0.834

High

894436

TIMP4
Metalloproteinase inhibitor 4

2

20

Small-scale

0.799

High

894451

JAM1
Junctional adhesion molecule A

2

2

High-throughput

0.783

High

774751

TIMP3
Metalloproteinase inhibitor 3

2

20

High-throughput

0.776

High

469712

MMP3
Stromelysin-1

1

5

Small-scale

0.692

High

488747

FURIN
Furin

3

2

Small-scale

0.650

High

894403

LUM
Lumican

2

0

Small-scale

0.598

High

690202

STOM
Stomatin

2

0

High-throughput

0.580

High

894413

FHL3
Four and a half LIM domains protein 3

2

0

High-throughput

0.580

High

894415

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.580

High

894417

MSMO1
Methylsterol monooxygenase 1

2

0

High-throughput

0.580

High

894425

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

0

High-throughput

0.580

High

894435

ZUP1
Zinc finger-containing ubiquitin peptidase 1

2

0

High-throughput

0.580

High

894402

MMP15
Matrix metalloproteinase-15

1

5

High-throughput

0.575

High

894409

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

2

Small-scale

0.561

High

894439

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.554

High

894405

RAD
GTP-binding protein RAD

1

1

High-throughput

0.541

High

894447

COR1C
Coronin-1C

1

0

Small-scale

0.537

High

456940

CO8A
Complement component C8 alpha chain

1

5

High-throughput

0.536

High

787622

SPB5
Serpin B5

1

3

High-throughput

0.536

High

894446

DKKL1
Dickkopf-like protein 1

1

2

High-throughput

0.536

High

894450

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.536

High

303061

CCN5
CCN family member 5

1

2

Small-scale

0.527

High

894448

PLLP
Plasmolipin

1

0

High-throughput

0.518

High

894428

S15A4
Solute carrier family 15 member 4

1

0

Small-scale

0.513

High

894432

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.513

High

894438

MTND
Acireductone dioxygenase

1

0

Small-scale

0.506

High

284503

TNR21
Tumor necrosis factor receptor superfamily member 21

1

2

Small-scale

0.501

High

378010

TNFA
Tumor necrosis factor

1

1

Small-scale

0.501

High

465951

CO1A2
Collagen alpha-2(I) chain

1

20

Small-scale

0.501

High

518773

IL8
Interleukin-8

1

20

Small-scale

0.501

High

709289

CCN2
CCN family member 2

1

2

Small-scale

0.501

High

894406

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

Small-scale

0.493

High

894419

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.493

High

894411

GALT1
Polypeptide N-acetylgalactosaminyltransferase 1

1

3

High-throughput

0.489

High

894441

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.489

High

641925

CD9
CD9 antigen

1

1

High-throughput

0.484

High

399403

SLPI
Antileukoproteinase

1

0

Small-scale

0.480

High

642531

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

Small-scale

0.480

High

275878

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

2

Small-scale

0.479

High

371487

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

641138

FGFR2
Fibroblast growth factor receptor 2

1

4

Small-scale

0.479

High

648461

FGFR4
Fibroblast growth factor receptor 4

1

4

Small-scale

0.479

High

894404

LIMK1
LIM domain kinase 1

1

6

Small-scale

0.479

High

894410

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

3

Small-scale

0.479

High

894414

EEA1
Early endosome antigen 1

1

3

High-throughput

0.479

High

894420

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

2

High-throughput

0.479

High

894424

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

894437

TICN3
Testican-3

1

4

Small-scale

0.479

High

894408

CAV1
Caveolin-1

1

0

Small-scale

0.458

High

894443

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

138463

BIN1
Myc box-dependent-interacting protein 1

1

2

High-throughput

0.445

High

161010

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

2

High-throughput

0.445

High

207803

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

3

High-throughput

0.445

High

349624

TSN12
Tetraspanin-12

1

1

Small-scale

0.445

High

362981

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.445

High

894407

DEF1
Neutrophil defensin 1

1

1

Small-scale

0.445

High

894423

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.445

High

894449

SHLB1
Endophilin-B1

1

1

High-throughput

0.445

High

894442

GORS2
Golgi reassembly-stacking protein 2

1

1

Small-scale

0.437

High

663351

KTHY
Thymidylate kinase

1

0

High-throughput

0.426

High

894418

TBCC
Tubulin-specific chaperone C

1

0

High-throughput

0.426

High

894426

SMAP1
Stromal membrane-associated protein 1

1

0

High-throughput

0.426

High

894427

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

894433

SETD7
Histone-lysine N-methyltransferase SETD7

1

0

High-throughput

0.426

High

894422

HECD3
E3 ubiquitin-protein ligase HECTD3

1

4

High-throughput

0.407

High

894412

AQP6
Aquaporin-6

2

0

High-throughput

0.316

High

894440

ELOV4
Very long chain fatty acid elongase 4

2

0

High-throughput

0.316

High

894429

KASH5
Protein KASH5

1

0

High-throughput

0.299

High

49637

T120B
Transmembrane protein 120B

1

0

High-throughput

0.279

Low

894430

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.279

Low

894431

GSTCD
Glutathione S-transferase C-terminal domain-containing protein

1

0

High-throughput

0.279

Low

894434

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

894444

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.279

Low

894421

TMM31
Transmembrane protein 31

1

0

High-throughput

0.251

Low

894445

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

894416

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025