HitPredict

Interactor 1: SNRPA (P09012)
U1 small nuclear ribonucleoprotein A (U1 snRNP A) (U1-A) (U1A)
Gene: SNRPA

Interactor 2: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.900

Property	Details
Experiments	35271311, 32707033, 23602568, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 282 Hs			1 688
+	Hs
		687380 PTBP1_HUMAN (1-281): 2.59e-55: 189: 20.42		SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00
+	Hs
		478172 SNRPA_HUMAN (1-282): 1.06e-59: 193: 100.00		SRPK1_HUMAN (27-688): 2.64e-125: 388: 53.00
+	Sc
		741091 PUB1_YEAST (11-282): 2.92e-39: 144: 18.25		SKY1_YEAST (1-686): 1.3e-117: 371: 30.50
+	Hs
		550226 PABP1_HUMAN (10-223): 3.85e-20: 91.9: 14.82		SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00
+	Hs
		550424 PABP1_HUMAN (10-223): 3.85e-20: 91.9: 14.82		SRPK1_HUMAN (27-688): 2.64e-125: 388: 53.00
+	Hs
		1006374 PABP4_HUMAN (11-199): 2.34e-18: 86.5: 18.42		SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00
+	Hs
		477919 SNRPA_HUMAN (1-282): 1.06e-59: 193: 100.00		CDK2_HUMAN (378-687): 2.51e-89: 282: 16.83
+	Hs
		667539 PTBP1_HUMAN (1-281): 2.59e-55: 189: 20.42		CDK2_HUMAN (378-687): 2.51e-89: 282: 16.83
+	Hs
		344093 PTBP3_HUMAN (2-281): 3.3e-49: 172: 19.44		CDK2_HUMAN (378-687): 2.51e-89: 282: 16.83
+	Hs
		478259 SNRPA_HUMAN (1-282): 1.06e-59: 193: 100.00		SRPK3_HUMAN (453-687): 8.64e-64: 223: 67.23
+	Hs
		477952 SNRPA_HUMAN (1-282): 1.06e-59: 193: 100.00		CLK2_HUMAN (62-229): 1.41e-63: 221: 33.73
+	Hs
		227157 RU2B_HUMAN (5-282): 1.38e-59: 190: 46.40		DYRK3_HUMAN (3-241): 4.59e-59: 211: 26.88
+	Hs
		344134 PTBP3_HUMAN (2-281): 3.3e-49: 172: 19.44		CLK3_HUMAN (62-240): 8.41e-62: 216: 31.11
+	Hs
		515832 RBY1A_HUMAN (1-280): 3.78e-46: 163: 17.48		CLK3_HUMAN (62-240): 8.41e-62: 216: 31.11
+	Hs
		889739 RBY1F_HUMAN (1-280): 7.91e-46: 162: 17.48		CLK3_HUMAN (62-240): 8.41e-62: 216: 31.11
+	Hs
		550125 PABP1_HUMAN (10-223): 3.85e-20: 91.9: 14.82		CDK2_HUMAN (378-687): 2.51e-89: 282: 16.83
+	Hs
		48039 RBM47_HUMAN (12-281): 2.31e-39: 146: 18.68		DYRK2_HUMAN (51-234): 1.49e-62: 221: 29.35
+	Hs
		550181 PABP1_HUMAN (10-223): 3.85e-20: 91.9: 14.82		CLK2_HUMAN (62-229): 1.41e-63: 221: 33.73
+	Hs
		550182 PABP1_HUMAN (10-223): 3.85e-20: 91.9: 14.82		CLK3_HUMAN (62-240): 8.41e-62: 216: 31.11
+	Hs
		889723 PABP4_HUMAN (11-199): 2.34e-18: 86.5: 18.42		CLK3_HUMAN (62-240): 8.41e-62: 216: 31.11