HitPredict

Interactor 1: FGR (P09769)
Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)
Gene: FGR

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	15707590
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008360 - regulation of cell shape
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 529 Hs			1 665
+	Hs
		440667 FYN_HUMAN (1-527): 0: 607: 69.94		SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00
+	Hs
		557424 SRC_HUMAN (1-527): 0: 595: 65.49		SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00
+	Hs
		473458 HCK_HUMAN (1-524): 0: 566: 56.30		SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00
+	Hs
		440171 LCK_HUMAN (1-527): 0: 563: 52.37		SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00
+	Hs
		440806 FYN_HUMAN (1-527): 0: 607: 69.94		CD2AP_HUMAN (1-664): 1.84e-95: 309: 32.36
+	Hs
		473487 HCK_HUMAN (1-524): 0: 566: 56.30		CD2AP_HUMAN (1-664): 1.84e-95: 309: 32.36
+	Hs
		440558 FYN_HUMAN (1-527): 0: 607: 69.94		CASL_HUMAN (2-656): 2.59e-38: 154: 11.91
+	Hs
		557342 SRC_HUMAN (1-527): 0: 595: 65.49		SPD2A_HUMAN (3-650): 8.88e-37: 150: 16.74
+	Mm
		813519 FYN_MOUSE (1-527): 0: 607: 69.76		GRB2_MOUSE (2-158): 8.55e-35: 133: 20.37
+	Hs
		557205 SRC_HUMAN (1-527): 0: 595: 65.49		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Mm
		813529 FYN_MOUSE (1-527): 0: 607: 69.76		NCK1_MOUSE (104-413): 1.87e-26: 113: 16.92
+	Hs
		440340 FYN_HUMAN (1-527): 0: 607: 69.94		NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62
+	Hs
		440075 LCK_HUMAN (1-527): 0: 563: 52.37		CASL_HUMAN (2-656): 2.59e-38: 154: 11.91
+	Hs
		463518 LYN_HUMAN (1-524): 0: 550: 53.91		CASL_HUMAN (2-656): 2.59e-38: 154: 11.91
+	Hs
		440576 FYN_HUMAN (1-527): 0: 607: 69.94		ITSN1_HUMAN (77-423): 3.02e-14: 78.9: 14.56
+	Hs
		440335 FYN_HUMAN (1-527): 0: 607: 69.94		VAV_HUMAN (84-158): 6.3e-13: 74.3: 28.95
+	Hs
		463564 LYN_HUMAN (1-524): 0: 550: 53.91		SH319_HUMAN (9-367): 1.66e-24: 111: 14.76
+	Hs
		439933 LCK_HUMAN (1-527): 0: 563: 52.37		VAV_HUMAN (84-158): 6.3e-13: 74.3: 28.95
+	Hs
		463538 LYN_HUMAN (1-524): 0: 550: 53.91		ITSN1_HUMAN (77-423): 3.02e-14: 78.9: 14.56
+	Hs
		463616 LYN_HUMAN (1-524): 0: 550: 53.91		SH3R1_HUMAN (62-166): 3.79e-09: 61.9: 20.00