HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: HERC3 (Q15034)
Probable E3 ubiquitin-protein ligase HERC3 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 3) (HECT-type E3 ubiquitin transferase HERC3)
Gene: HERC3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	11163799
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 1050
+	Hs
		508091 UBC_HUMAN (1-685): 0: 857: 100.00		HERC4_HUMAN (1-1049): 0: 1077: 55.72
+	Hs
		507863 UBC_HUMAN (1-685): 0: 857: 100.00		UBE3A_HUMAN (448-1049): 0: 551: 27.87
+	Hs
		508443 UBC_HUMAN (1-685): 0: 857: 100.00		ITCH_HUMAN (604-1048): 4.43e-179: 547: 26.60
+	Hs
		131690 UBC_HUMAN (1-685): 0: 857: 100.00		WWP2_HUMAN (573-1048): 2.74e-177: 541: 23.06
+	Hs
		508598 UBC_HUMAN (1-685): 0: 857: 100.00		WWP1_HUMAN (605-1048): 2.3e-174: 535: 24.09
+	Hs
		508666 UBC_HUMAN (1-685): 0: 857: 100.00		SMUF1_HUMAN (596-1047): 3.42e-175: 532: 25.91
+	Hs
		507665 UBC_HUMAN (1-685): 0: 857: 100.00		NEDD4_HUMAN (604-1048): 1.83e-168: 531: 24.02
+	Hs
		508467 UBC_HUMAN (1-685): 0: 857: 100.00		NED4L_HUMAN (606-1048): 5.79e-171: 528: 25.21
+	Hs
		508655 UBC_HUMAN (1-685): 0: 857: 100.00		SMUF2_HUMAN (557-1047): 3.02e-172: 524: 23.66
+	Rn
		1221048 UBC_RAT (1-637): 0: 779: 98.90		Q5YB86_RAT (604-1048): 2.25e-180: 549: 26.60
+	Mm
		509115 UBC_MOUSE (1-108): 2.12e-30: 129: 90.74		HERC4_MOUSE (1-1049): 0: 1105: 55.35
+	Dm
		94225 UBIQP_DROME (1-610): 0: 759: 99.84		D5SHR3_DROME (692-1049): 1.21e-152: 462: 29.92
+	Dm
		1489825 Q9W418_DROME (229-685): 0: 567: 99.78		Q9W325_DROME (692-1049): 2.39e-152: 461: 29.92
+	Hs
		508027 UBC_HUMAN (1-685): 0: 857: 100.00		HERC1_HUMAN (22-163): 6.59e-11: 69.3: 30.82
+	Rn
		93331 UBC_RAT (1-637): 0: 779: 98.90		D4ACN3_RAT (129-341): 2.2e-17: 90.5: 26.12
+	Sc
		509564 UBI4P_YEAST (381-685): 4.09e-126: 380: 95.74		RSP5_YEAST (683-1048): 7.87e-158: 489: 29.18
+	Hs
		131925 RS27A_HUMAN (609-684): 7.26e-41: 148: 100.00		WWP2_HUMAN (573-1048): 2.74e-177: 541: 23.06
+	Hs
		987205 RS27A_HUMAN (609-684): 7.26e-41: 148: 100.00		WWP1_HUMAN (605-1048): 2.3e-174: 535: 24.09
+	Mm
		509071 UBC_MOUSE (1-108): 2.12e-30: 129: 90.74		HERC2_MOUSE (129-341): 2.07e-17: 90.5: 26.12
+	Mm
		97808 UBC_MOUSE (1-108): 2.12e-30: 129: 90.74		E9PZP8_MOUSE (22-163): 2.11e-10: 67.4: 29.45