HitPredict

Interactor 1: IL8 (P10145)
Interleukin-8 (IL-8) (C-X-C motif chemokine 8) (Chemokine (C-X-C motif) ligand 8) (Emoctakin) (Granulocyte chemotactic protein 1) (GCP-1) (Monocyte-derived neutrophil chemotactic factor) (MDNCF) (Monocyte-derived neutrophil-activating peptide) (MONAP) (Neutrophil-activating protein 1) (NAP-1) (Protein 3-10C) (T-cell chemotactic factor) [Cleaved into: MDNCF-a (GCP/IL-8 protein IV) (IL8/NAP1 form I); Interleukin-8 ((Ala-IL-8)77) (GCP/IL-8 protein II) (IL-8(1-77)) (IL8/NAP1 form II) (MDNCF-b); IL-8(5-77); IL-8(6-77) ((Ser-IL-8)72) (GCP/IL-8 protein I) (IL8/NAP1 form III) (Lymphocyte-derived neutrophil-activating factor) (LYNAP) (MDNCF-c) (Neutrophil-activating factor) (NAF); IL-8(7-77) (GCP/IL-8 protein V) (IL8/NAP1 form IV); IL-8(8-77) (GCP/IL-8 protein VI) (IL8/NAP1 form V); IL-8(9-77) (GCP/IL-8 protein III) (IL8/NAP1 form VI)]
Gene: CXCL8

Interactor 2: MMP14 (P50281)
Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)
Gene: MMP14

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	15255181
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001525 - angiogenesis GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 99 Hs			1 582
+	Hs
		518769 IL8_HUMAN (1-99): 1.27e-30: 105: 100.00		MMP12_HUMAN (11-508): 0: 575: 36.74
+	Hs
		518771 IL8_HUMAN (1-99): 1.27e-30: 105: 100.00		MMP13_HUMAN (1-504): 0: 575: 34.24
+	Hs
		399261 IL8_HUMAN (1-99): 1.27e-30: 105: 100.00		MMP1_HUMAN (16-508): 0: 570: 35.34
+	Hs
		814894 CXCL5_HUMAN (14-96): 2.18e-26: 95.5: 31.33		MMP12_HUMAN (11-508): 0: 575: 36.74
+	Hs
		390322 CXCL7_HUMAN (28-99): 1.44e-24: 91.3: 45.83		MMP12_HUMAN (11-508): 0: 575: 36.74
+	Hs
		399270 CXCL5_HUMAN (14-96): 2.18e-26: 95.5: 31.33		MMP1_HUMAN (16-508): 0: 570: 35.34
+	Hs
		480488 GROA_HUMAN (27-99): 1.72e-24: 90.5: 42.47		MMP12_HUMAN (11-508): 0: 575: 36.74
+	Hs
		626423 CXCL2_HUMAN (23-99): 1.45e-24: 90.5: 40.26		MMP12_HUMAN (11-508): 0: 575: 36.74
+	Hs
		518763 IL8_HUMAN (1-99): 1.27e-30: 105: 100.00		MMP8_HUMAN (16-508): 0: 557: 33.60
+	Hs
		390313 CXCL7_HUMAN (28-99): 1.44e-24: 91.3: 45.83		MMP1_HUMAN (16-508): 0: 570: 35.34
+	Hs
		399268 CXCL2_HUMAN (23-99): 1.45e-24: 90.5: 40.26		MMP1_HUMAN (16-508): 0: 570: 35.34
+	Hs
		399275 CXCL6_HUMAN (21-96): 3.85e-24: 89.8: 30.26		MMP1_HUMAN (16-508): 0: 570: 35.34
+	Hs
		653760 CXCL5_HUMAN (14-96): 2.18e-26: 95.5: 31.33		MMP8_HUMAN (16-508): 0: 557: 33.60
+	Mm
		762098 CXCL5_MOUSE (7-97): 1.46e-26: 96.7: 35.87		MMP12_MOUSE (12-508): 0: 533: 33.20
+	Mm
		533539 CXCL2_MOUSE (16-99): 7.04e-26: 94: 40.48		MMP12_MOUSE (12-508): 0: 533: 33.20
+	Mm
		762099 CXCL3_MOUSE (16-99): 1.6e-24: 90.5: 39.29		MMP12_MOUSE (12-508): 0: 533: 33.20
+	Hs
		518756 IL8_HUMAN (1-99): 1.27e-30: 105: 100.00		MMP9_HUMAN (4-224): 5.78e-65: 227: 36.20
+	Hs
		575782 CXCL5_HUMAN (14-96): 2.18e-26: 95.5: 31.33		MMP9_HUMAN (4-224): 5.78e-65: 227: 36.20
+	Hs
		390316 CXCL7_HUMAN (28-99): 1.44e-24: 91.3: 45.83		MMP9_HUMAN (4-224): 5.78e-65: 227: 36.20
+	Hs
		575777 CXCL2_HUMAN (23-99): 1.45e-24: 90.5: 40.26		MMP9_HUMAN (4-224): 5.78e-65: 227: 36.20