HitPredict

Interactor 1: A1Z6I7 (A1Z6I7)
Bub1-related kinase
Gene: BubR1

Interactor 2: Q24044 (Q24044)
Cell division cycle protein 20 homolog (p55CDC)
Gene: fzy

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	23685359, 26553926, 31913420, 20421417
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000776 - kinetochore
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1460 Dm			1 526
+	Mm
		632520 KPCA_MOUSE (955-1456): 6.66e-123: 400: 12.23		FBXW7_MOUSE (149-522): 7.97e-88: 286: 20.69
+	Hs
		728368 AKT1_HUMAN (1063-1458): 3.91e-121: 389: 13.55		FBXW7_HUMAN (149-522): 2.33e-87: 285: 20.69
+	Ce
		1067114 BUB1_CAEEL (919-1456): 3.3e-87: 309: 22.34		FZY1_CAEEL (45-504): 6.75e-120: 364: 27.81
+	Mm
		1440862 BUB1B_MOUSE (687-1459): 3.9e-73: 268: 13.93		CDC20_MOUSE (1-526): 8.16e-114: 348: 50.28
+	Hs
		224110 BUB1_HUMAN (41-287): 1.35e-71: 263: 30.77		CDC20_HUMAN (1-526): 6.23e-114: 348: 49.72
+	Hs
		251747 BUB1B_HUMAN (627-1457): 3.37e-64: 240: 14.76		CDC20_HUMAN (1-526): 6.23e-114: 348: 49.72
+	Hs
		964971 MYLK_HUMAN (601-1460): 6.95e-125: 432: 13.15		WDR5_HUMAN (368-512): 1.08e-36: 140: 19.86
+	Hs
		348179 M4K4_HUMAN (1175-1450): 2.83e-51: 200: 26.42		FBXW7_HUMAN (149-522): 2.33e-87: 285: 20.69
+	Hs
		728479 AKT1_HUMAN (1063-1458): 3.91e-121: 389: 13.55		FZR1_HUMAN (17-329): 1.59e-18: 90.5: 11.98
+	At
		199307 BUBR1_ARATH (2-330): 5.18e-102: 333: 26.87		CDC22_ARATH (355-523): 3.1e-24: 107: 16.86
+	At
		199308 BUBR1_ARATH (2-330): 5.18e-102: 333: 26.87		CDC21_ARATH (355-523): 2.59e-24: 107: 16.86
+	Hs
		224180 BUB1_HUMAN (41-287): 1.35e-71: 263: 30.77		FZR1_HUMAN (17-329): 1.59e-18: 90.5: 11.98
+	Hs
		251824 BUB1B_HUMAN (627-1457): 3.37e-64: 240: 14.76		FZR1_HUMAN (17-329): 1.59e-18: 90.5: 11.98
+	Hs
		845359 TNIK_HUMAN (1175-1450): 8.61e-48: 189: 24.84		LIS1_HUMAN (130-321): 1.24e-31: 128: 9.96
+	Sc
		684627 BUB1_YEAST (28-419): 2.08e-60: 228: 15.87		CDC20_YEAST (37-385): 5.77e-12: 70.2: 16.14
+	At
		1424716 Q9FFG4_ARATH (26-195): 5.62e-50: 186: 24.71		CDC22_ARATH (355-523): 3.1e-24: 107: 16.86
+	At
		1424717 Q9FFG4_ARATH (26-195): 5.62e-50: 186: 24.71		CDC21_ARATH (355-523): 2.59e-24: 107: 16.86
+	Sc
		684630 MAD3_YEAST (2-275): 5.5e-59: 214: 24.21		CDC20_YEAST (37-385): 5.77e-12: 70.2: 16.14