HitPredict

Interactor 1: KAPC1 (P12370)
cAMP-dependent protein kinase catalytic subunit 1 (PKA C) (EC 2.7.11.11) (Protein kinase DC0)
Gene: Pka-C1

Interactor 2: FUSED (P23647)
Serine/threonine-protein kinase fused (EC 2.7.11.1)
Gene: fu

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	25289679, 30541874, 22036573
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005829 - cytosol GO:0045879 - negative regulation of smoothened signaling pathway GO:0106310 - protein serine kinase activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 353 Dm			1 805
+	Hs
		568551 KAPCA_HUMAN (1-353): 7.35e-158: 447: 82.44		MARK3_HUMAN (1-667): 5.28e-137: 425: 20.29
+	Hs
		568791 KAPCA_HUMAN (1-353): 7.35e-158: 447: 82.44		SIK2_HUMAN (4-666): 4.22e-134: 422: 19.16
+	Hs
		568714 KAPCA_HUMAN (1-353): 7.35e-158: 447: 82.44		MARK2_HUMAN (1-559): 1.86e-133: 417: 20.57
+	Hs
		682207 AKT2_HUMAN (2-349): 7.93e-151: 435: 35.80		SIK2_HUMAN (4-666): 4.22e-134: 422: 19.16
+	Hs
		681985 AKT1_HUMAN (20-349): 3.04e-147: 425: 38.81		MARK4_HUMAN (1-636): 2.4e-136: 423: 19.30
+	Hs
		568561 KAPCA_HUMAN (1-353): 7.35e-158: 447: 82.44		AKT1_HUMAN (1-325): 6.06e-130: 397: 29.13
+	Hs
		681915 AKT1_HUMAN (20-349): 3.04e-147: 425: 38.81		MARK2_HUMAN (1-559): 1.86e-133: 417: 20.57
+	Hs
		682218 AKT2_HUMAN (2-349): 7.93e-151: 435: 35.80		AKT3_HUMAN (1-325): 9.17e-132: 402: 28.92
+	Hs
		681681 AKT2_HUMAN (2-349): 7.93e-151: 435: 35.80		AKT1_HUMAN (1-325): 6.06e-130: 397: 29.13
+	Hs
		682081 AKT3_HUMAN (27-349): 2.71e-149: 430: 40.06		AKT1_HUMAN (1-325): 6.06e-130: 397: 29.13
+	Mm
		682096 AKT1_MOUSE (20-349): 7.62e-148: 427: 39.10		AKT1_MOUSE (1-325): 2.95e-130: 398: 28.83
+	Hs
		681680 AKT1_HUMAN (20-349): 3.04e-147: 425: 38.81		AKT1_HUMAN (1-325): 6.06e-130: 397: 29.13
+	Hs
		616676 KS6B1_HUMAN (25-352): 1.55e-141: 412: 35.12		AKT1_HUMAN (1-325): 6.06e-130: 397: 29.13
+	Hs
		682054 KS6B2_HUMAN (28-352): 1.06e-141: 412: 36.04		AKT1_HUMAN (1-325): 6.06e-130: 397: 29.13
+	Dm
		1118051 AKT1_DROME (1-345): 6.6e-150: 437: 37.57		Q4QQA7_DROME (4-301): 1.35e-37: 152: 32.78
+	At
		791105 KPK1_ARATH (10-338): 7.27e-142: 411: 34.94		KPK1_ARATH (1-243): 8.87e-42: 160: 36.59
+	Hs
		1285843 SGK2_HUMAN (45-341): 8.2e-138: 397: 42.72		SGK3_HUMAN (9-255): 2.29e-37: 148: 35.83