Protein: NLK
Serine/threonine-protein kinase NLK (EC 2.7.11.24) (Nemo-like kinase) (Protein LAK1)

Gene: NLK
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q9UBE8

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458343

NLK
Serine/threonine-protein kinase NLK

6

16

Small-scale

0.934

High

1458348

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

2

13

High-throughput

0.811

High

214052

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

15

Small-scale

0.759

High

857577

NOTC1
Neurogenic locus notch homolog protein 1

1

2

Small-scale

0.724

High

1458346

LEF1
Lymphoid enhancer-binding factor 1

5

7

Small-scale

0.710

High

1433683

ZHX3
Zinc fingers and homeoboxes protein 3

4

1

High-throughput

0.703

High

854761

RAGP1
Ran GTPase-activating protein 1

1

5

High-throughput

0.691

High

923372

MK12
Mitogen-activated protein kinase 12

1

18

High-throughput

0.691

High

1401331

PASK
PAS domain-containing serine/threonine-protein kinase

1

10

High-throughput

0.691

High

705588

GRN
Progranulin

3

4

High-throughput

0.683

High

1432276

HIPK2
Homeodomain-interacting protein kinase 2

1

18

Small-scale

0.680

High

519430

MYB
Transcriptional activator Myb

2

20

Small-scale

0.657

High

1106732

SMAD4
Mothers against decapentaplegic homolog 4

2

7

High-throughput

0.647

High

1356269

F222B
Protein FAM222B

2

1

High-throughput

0.628

High

1453502

CNOT2
CCR4-NOT transcription complex subunit 2

2

1

High-throughput

0.628

High

1458345

TRPS1
Zinc finger transcription factor Trps1

2

7

High-throughput

0.628

High

927590

ATX1
Ataxin-1

2

2

High-throughput

0.620

High

212691

DAPK3
Death-associated protein kinase 3

1

20

Small-scale

0.618

High

1217063

F222A
Protein FAM222A

3

5

High-throughput

0.616

High

1458344

NDOR1
NADPH-dependent diflavin oxidoreductase 1

2

2

High-throughput

0.606

High

844046

HD
Huntingtin

2

3

Small-scale

0.601

High

1368502

CBP
CREB-binding protein

2

9

Small-scale

0.595

High

519455

MYBA
Myb-related protein A

1

20

Small-scale

0.578

High

1435095

WDCP
WD repeat and coiled-coil-containing protein

2

1

High-throughput

0.574

High

685968

KRA59
Keratin-associated protein 5-9

1

3

High-throughput

0.573

High

1180196

QRIC1
Transcriptional regulator QRICH1

1

4

High-throughput

0.573

High

1419100

KRA42
Keratin-associated protein 4-2

1

2

High-throughput

0.573

High

414764

P53
Cellular tumor antigen p53

1

8

Small-scale

0.561

High

1023216

FOXO4
Forkhead box protein O4

1

5

Small-scale

0.561

High

1094645

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

3

Small-scale

0.561

High

1420204

FOXP3
Forkhead box protein P3

1

4

Small-scale

0.561

High

1452629

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

3

Small-scale

0.561

High

1399858

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.558

High

1235856

KRA56
Keratin-associated protein 5-6

1

0

High-throughput

0.549

High

1325568

RDHE2
Epidermal retinol dehydrogenase 2

1

1

High-throughput

0.541

High

166578

BACH1
Transcription regulator protein BACH1

1

5

High-throughput

0.536

High

213265

CP110
Centriolar coiled-coil protein of 110 kDa

1

1

High-throughput

0.536

High

273944

CNOT3
CCR4-NOT transcription complex subunit 3

1

5

High-throughput

0.536

High

573270

KPYM
Pyruvate kinase PKM

1

6

High-throughput

0.536

High

890606

RBP2
E3 SUMO-protein ligase RanBP2

1

3

High-throughput

0.536

High

1048119

TLE3
Transducin-like enhancer protein 3

1

5

High-throughput

0.536

High

1122186

UBP2L
Ubiquitin-associated protein 2-like

1

5

High-throughput

0.536

High

1134414

IMB1
Importin subunit beta-1

1

5

High-throughput

0.536

High

1309500

CEP97
Centrosomal protein of 97 kDa

1

1

High-throughput

0.536

High

1420825

TB182
182 kDa tankyrase-1-binding protein

1

8

High-throughput

0.536

High

555435

SKI
Ski oncogene

1

0

High-throughput

0.513

High

1414169

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

1458347

CNO11
CCR4-NOT transcription complex subunit 11

1

0

High-throughput

0.513

High

1322665

RPTOR
Regulatory-associated protein of mTOR

1

9

Small-scale

0.501

High

827951

STAT3
Signal transducer and activator of transcription 3

1

6

Small-scale

0.484

High

949790

KR101
Keratin-associated protein 10-1

1

2

High-throughput

0.481

High

950026

KR103
Keratin-associated protein 10-3

1

2

High-throughput

0.481

High

219755

FOXO3
Forkhead box protein O3

1

9

Small-scale

0.479

High

519572

MYBB
Myb-related protein B

1

20

Small-scale

0.479

High

623579

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

High-throughput

0.479

High

765080

CTNB1
Catenin beta-1

1

9

Small-scale

0.479

High

776291

SOX11
Transcription factor SOX-11

1

5

Small-scale

0.479

High

862512

YAP1
Transcriptional coactivator YAP1

1

5

Small-scale

0.479

High

945598

FBXW4
F-box/WD repeat-containing protein 4

1

9

Small-scale

0.479

High

1085635

FOXO1
Forkhead box protein O1

1

8

Small-scale

0.479

High

1101918

SKP2
S-phase kinase-associated protein 2

1

3

Small-scale

0.479

High

1112755

CUL1
Cullin-1

1

5

Small-scale

0.479

High

1122871

TFDP1
Transcription factor Dp-1

1

6

Small-scale

0.479

High

1202253

DCAF6
DDB1- and CUL4-associated factor 6

1

6

High-throughput

0.479

High

1446886

TF7L2
Transcription factor 7-like 2

1

7

Small-scale

0.479

High

1005203

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1028430

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

1381296

FBXW5
F-box/WD repeat-containing protein 5

1

0

Small-scale

0.458

High

1219902

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.279

Low

455941

ASGR1
Asialoglycoprotein receptor 1

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025