HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ACTA (P62736)
Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form]
Gene: ACTA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0044297 - cell body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 377
+	Hs
		529919 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Hs
		529591 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ACTC_HUMAN (1-377): 0: 595: 98.41
+	Hs
		529594 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ACTS_HUMAN (1-377): 0: 595: 97.88
+	Hs
		529461 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ACTB_HUMAN (4-377): 0: 594: 94.12
+	Hs
		529584 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ACTG_HUMAN (4-377): 0: 594: 94.39
+	Hs
		590291 MUC1_HUMAN (39-730): 2.41e-41: 165: 11.50		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Mm
		530781 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		ACTC_MOUSE (1-377): 0: 595: 98.41
+	Hs
		1200982 SRCAP_HUMAN (168-756): 9.46e-12: 71.2: 11.72		ACTBL_HUMAN (4-377): 0: 712: 87.97
+	Hs
		590266 MUC1_HUMAN (39-730): 2.41e-41: 165: 11.50		ACTA_HUMAN (1-377): 0: 593: 100.00
+	Hs
		536330 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		ACTB_HUMAN (4-377): 0: 594: 94.12
+	Ce
		534409 Q95QG4_CAEEL (411-693): 6.64e-25: 110: 29.33		ACT4_CAEEL (1-377): 0: 596: 93.90
+	Ce
		115062 H2KY94_CAEEL (465-688): 3.04e-25: 107: 33.48		ACT4_CAEEL (1-377): 0: 596: 93.90
+	Hs
		995592 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		ACTC_HUMAN (1-377): 0: 595: 98.41
+	Hs
		215916 SYNJ1_HUMAN (173-636): 8.49e-14: 77.6: 14.41		ACTC_HUMAN (1-377): 0: 595: 98.41
+	Ce
		146065 O02592_CAEEL (353-709): 1.53e-13: 75.7: 21.29		ACT4_CAEEL (1-377): 0: 596: 93.90
+	Hs
		995656 SRCAP_HUMAN (168-756): 9.46e-12: 71.2: 11.72		ACTC_HUMAN (1-377): 0: 595: 98.41
+	Hs
		952913 SRCAP_HUMAN (168-756): 9.46e-12: 71.2: 11.72		ACTB_HUMAN (4-377): 0: 594: 94.12
+	Hs
		993223 SRCAP_HUMAN (168-756): 9.46e-12: 71.2: 11.72		ACTG_HUMAN (4-377): 0: 594: 94.39
+	Dm
		534353 CPN_DROME (353-756): 7.79e-12: 70.8: 13.55		ACT5_DROME (1-377): 0: 593: 92.57
+	Hs
		995780 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		ACTC_HUMAN (1-377): 0: 595: 98.41