HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: ACTBL (Q562R1)
Beta-actin-like protein 2 (Kappa-actin)
Gene: ACTBL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	36634849, 26269332, 35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0019901 - protein kinase binding GO:0030424 - axon
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 758 Hs			1 376
+	Hs
		529461 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		529584 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ACTG_HUMAN (3-376): 0: 594: 91.44
+	Hs
		529591 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ACTC_HUMAN (2-376): 0: 589: 88.27
+	Hs
		529594 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ACTS_HUMAN (2-376): 0: 588: 87.47
+	Hs
		529537 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		ACTA_HUMAN (1-376): 0: 586: 87.80
+	Mm
		530781 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		ACTC_MOUSE (2-376): 0: 589: 88.27
+	Hs
		590291 MUC1_HUMAN (39-730): 2.41e-41: 165: 11.50		ACTBL_HUMAN (1-376): 0: 615: 100.00
+	Hs
		590266 MUC1_HUMAN (39-730): 2.41e-41: 165: 11.50		ACTA_HUMAN (1-376): 0: 586: 87.80
+	Hs
		536330 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Ce
		534409 Q95QG4_CAEEL (411-693): 6.64e-25: 110: 29.33		ACT4_CAEEL (1-376): 0: 599: 90.16
+	Ce
		115062 H2KY94_CAEEL (465-688): 3.04e-25: 107: 33.48		ACT4_CAEEL (1-376): 0: 599: 90.16
+	Hs
		1200982 SRCAP_HUMAN (168-756): 9.46e-12: 71.2: 11.72		ACTBL_HUMAN (1-376): 0: 615: 100.00
+	Hs
		995592 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		ACTC_HUMAN (2-376): 0: 589: 88.27
+	Ce
		146065 O02592_CAEEL (353-709): 1.53e-13: 75.7: 21.29		ACT4_CAEEL (1-376): 0: 599: 90.16
+	Dm
		534353 CPN_DROME (353-756): 7.79e-12: 70.8: 13.55		ACT5_DROME (1-376): 0: 597: 89.10
+	Hs
		215916 SYNJ1_HUMAN (173-636): 8.49e-14: 77.6: 14.41		ACTC_HUMAN (2-376): 0: 589: 88.27
+	Hs
		952913 SRCAP_HUMAN (168-756): 9.46e-12: 71.2: 11.72		ACTB_HUMAN (3-376): 0: 595: 91.71
+	Hs
		993223 SRCAP_HUMAN (168-756): 9.46e-12: 71.2: 11.72		ACTG_HUMAN (3-376): 0: 594: 91.44
+	Hs
		995656 SRCAP_HUMAN (168-756): 9.46e-12: 71.2: 11.72		ACTC_HUMAN (2-376): 0: 589: 88.27
+	Hs
		995780 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		ACTC_HUMAN (2-376): 0: 589: 88.27