HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 772
+	Hs
		529673 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		TLE4_HUMAN (1-772): 0: 541: 80.52
+	Hs
		1048069 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		TLE3_HUMAN (1-772): 0: 597: 100.00
+	Hs
		161453 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		TLE3_HUMAN (1-772): 0: 597: 100.00
+	Hs
		529281 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		LIS1_HUMAN (572-770): 8.55e-60: 210: 17.57
+	Hs
		529555 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		GBB2_HUMAN (369-646): 6.82e-46: 169: 16.90
+	Hs
		529553 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		GBB1_HUMAN (567-770): 2.96e-38: 147: 17.62
+	Hs
		209193 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		PRP4_HUMAN (555-763): 6.51e-12: 70.9: 28.24
+	Mm
		530763 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		GNB5_MOUSE (485-768): 4.55e-13: 73.6: 23.83
+	Hs
		161490 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		POC1A_HUMAN (563-770): 2.12e-62: 216: 22.28
+	Hs
		984123 SPEG_HUMAN (183-564): 2.89e-23: 108: 16.71		GBB2_HUMAN (369-646): 6.82e-46: 169: 16.90
+	Hs
		698256 MAP4_HUMAN (22-721): 3.01e-10: 66.2: 9.24		WDR5_HUMAN (238-560): 1.08e-30: 125: 8.46
+	Hs
		161486 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		WDR5B_HUMAN (235-559): 7.52e-32: 128: 8.71
+	Hs
		965173 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		WDR5_HUMAN (238-560): 1.08e-30: 125: 8.46
+	Hs
		161443 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		WDR5_HUMAN (238-560): 1.08e-30: 125: 8.46
+	Hs
		965097 KMT2C_HUMAN (228-752): 7.28e-09: 62: 7.94		WDR5_HUMAN (238-560): 1.08e-30: 125: 8.46
+	Mm
		965395 KMT2C_MOUSE (228-587): 6.08e-09: 61.9: 16.84		WDR5_MOUSE (238-560): 1.08e-30: 125: 8.46
+	Hs
		1129693 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		SNR40_HUMAN (509-677): 5.37e-09: 60.8: 26.52