HitPredict

Interactor 1: MYPT1 (O14974)
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)
Gene: PPP1R12A

Interactor 2: TARA (Q9H2D6)
TRIO and F-actin-binding protein (Protein Tara) (TRF1-associated protein of 68 kDa) (Trio-associated repeat on actin)
Gene: TRIOBP

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	0.60	0.554

Property	Details
Experiments	28330616
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005813 - centrosome GO:0005925 - focal adhesion GO:0015629 - actin cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1030 Hs			1 2365
+	Hs
		161391 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		MPRIP_HUMAN (1554-2357): 2.27e-56: 217: 33.82
+	Hs
		161319 MYPT1_HUMAN (1-1030): 4.91e-140: 448: 100.00		MYH9_HUMAN (1312-2225): 5.12e-28: 126: 8.32
+	Hs
		1167443 ANR50_HUMAN (22-935): 8.69e-65: 241: 13.09		MPRIP_HUMAN (1554-2357): 2.27e-56: 217: 33.82
+	Hs
		1167417 PP12C_HUMAN (538-1030): 4.93e-33: 139: 20.35		MPRIP_HUMAN (1554-2357): 2.27e-56: 217: 33.82
+	Hs
		1189816 ANR50_HUMAN (22-935): 8.69e-65: 241: 13.09		MYH14_HUMAN (2035-2363): 1.9e-15: 85.4: 15.06
+	Hs
		883487 RIPK4_HUMAN (1-326): 1.53e-70: 253: 20.06		ANK2_HUMAN (28-1012): 2.01e-09: 65.7: 14.82
+	Hs
		965154 Q9H4D1_HUMAN (1-326): 3.17e-70: 251: 20.06		ANK2_HUMAN (28-1012): 2.01e-09: 65.7: 14.82
+	Hs
		1056981 TNKS2_HUMAN (1-611): 2.38e-60: 227: 12.05		MDC1_HUMAN (88-903): 1.81e-15: 85.4: 14.49
+	Hs
		310053 TNKS1_HUMAN (1-682): 9.92e-60: 225: 12.67		MDC1_HUMAN (88-903): 1.81e-15: 85.4: 14.49
+	Dm
		1303397 Q9VJ14_DROME (140-612): 6.22e-24: 111: 14.07		MYSN_DROME (1678-2364): 1.82e-45: 184: 12.70
+	Hs
		862028 DAPK1_HUMAN (43-515): 3.48e-54: 208: 15.55		ANK2_HUMAN (28-1012): 2.01e-09: 65.7: 14.82
+	Dm
		1361443 Q9VAU5_DROME (4-789): 1.18e-51: 201: 13.90		Q9VLS7_DROME (138-844): 3.51e-09: 64.9: 14.37
+	Hs
		225128 MYPT2_HUMAN (1-905): 6.08e-21: 101: 11.37		MYH9_HUMAN (1312-2225): 5.12e-28: 126: 8.32
+	Hs
		166913 ANR28_HUMAN (1-175): 3.5e-38: 156: 20.99		ANK2_HUMAN (28-1012): 2.01e-09: 65.7: 14.82
+	Mm
		57429 A2AM57_MOUSE (152-919): 6.73e-16: 84.9: 8.55		MYH9_MOUSE (1813-2365): 4.87e-30: 133: 12.21
+	Mm
		103608 ANK3_MOUSE (165-457): 5.34e-24: 111: 12.50		ANK2_MOUSE (61-1013): 1.59e-12: 75.7: 15.18
+	Mm
		57416 A2AM57_MOUSE (152-919): 6.73e-16: 84.9: 8.55		Q6S385_MOUSE (1893-2355): 2.22e-18: 95.4: 16.26
+	Mm
		57340 A2AM57_MOUSE (152-919): 6.73e-16: 84.9: 8.55		DESP_MOUSE (1531-2365): 5.7e-16: 87.3: 9.76
+	Dm
		1182373 Q7KU92_DROME (100-427): 2.38e-22: 106: 14.04		Q9VLS7_DROME (138-844): 3.51e-09: 64.9: 14.37
+	Hs
		225134 MYPT2_HUMAN (1-905): 6.08e-21: 101: 11.37		ANK2_HUMAN (28-1012): 2.01e-09: 65.7: 14.82