HitPredict

Interactor 1: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Interactor 2: NTRK3 (Q16288)
NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)
Gene: NTRK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 803 Hs			1 839
+	Hs
		438205 HS90B_HUMAN (75-783): 0: 997: 46.54		NTRK3_HUMAN (1-839): 0: 671: 100.00
+	Hs
		384200 ENPL_HUMAN (1-803): 0: 1073: 100.00		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		438213 HS90B_HUMAN (75-783): 0: 997: 46.54		NTRK2_HUMAN (6-839): 0: 557: 52.87
+	Hs
		384122 HS90B_HUMAN (75-783): 0: 997: 46.54		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		437897 HS90B_HUMAN (75-783): 0: 997: 46.54		FGFR3_HUMAN (140-838): 3.83e-170: 514: 23.73
+	Hs
		384111 HS90A_HUMAN (60-783): 0: 990: 45.34		NTRK1_HUMAN (16-839): 8.14e-173: 520: 46.75
+	Hs
		437838 HS90B_HUMAN (75-783): 0: 997: 46.54		FGFR1_HUMAN (162-838): 5.94e-163: 496: 23.43
+	Hs
		437895 HS90B_HUMAN (75-783): 0: 997: 46.54		FGFR4_HUMAN (166-837): 6.43e-152: 466: 24.57
+	Hs
		431435 HS90A_HUMAN (60-783): 0: 990: 45.34		RET_HUMAN (282-837): 1.5e-108: 360: 25.76
+	Hs
		411287 ENPL_HUMAN (1-803): 0: 1073: 100.00		INSR_HUMAN (513-824): 1.34e-64: 238: 39.43
+	Hs
		435523 ENPL_HUMAN (1-803): 0: 1073: 100.00		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Rn
		544887 ENPL_RAT (1-803): 0: 1055: 95.03		INSR_RAT (513-824): 3.31e-62: 230: 38.80
+	Hs
		438220 HS90B_HUMAN (75-783): 0: 997: 46.54		DDR2_HUMAN (527-824): 2.05e-70: 250: 43.30
+	Hs
		438084 HS90B_HUMAN (75-783): 0: 997: 46.54		ROR2_HUMAN (522-828): 2.97e-67: 243: 41.56
+	Hs
		435497 HS90B_HUMAN (75-783): 0: 997: 46.54		IGF1R_HUMAN (513-820): 3.56e-64: 236: 39.16
+	Hs
		437855 HS90B_HUMAN (75-783): 0: 997: 46.54		INSRR_HUMAN (513-820): 1.33e-62: 231: 40.84
+	Hs
		438619 HS90B_HUMAN (75-783): 0: 997: 46.54		ALK_HUMAN (513-816): 2.78e-59: 222: 39.03
+	Hs
		437967 HS90B_HUMAN (75-783): 0: 997: 46.54		FRK_HUMAN (533-814): 5.68e-57: 205: 37.23
+	Hs
		169160 HS90B_HUMAN (75-783): 0: 997: 46.54		MUSK_HUMAN (209-391): 1.75e-22: 105: 24.60
+	Hs
		169159 HS90A_HUMAN (60-783): 0: 990: 45.34		MUSK_HUMAN (209-391): 1.75e-22: 105: 24.60