HitPredict

Interactor 1: IDE (P14735)
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)
Gene: IDE

Interactor 2: NEST (P48681)
Nestin
Gene: NES

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

Property	Details
Experiments	26496610, 21185309, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1019 Hs			1 1621
+	Hs
		443298 IDE_HUMAN (1-1019): 0: 1084: 100.00		VIME_HUMAN (8-343): 3.05e-118: 382: 28.32
+	Hs
		535317 IDE_HUMAN (1-1019): 0: 1084: 100.00		GFAP_HUMAN (8-316): 8.2e-22: 102: 30.35
+	Hs
		422141 IDE_HUMAN (1-1019): 0: 1084: 100.00		NFL_HUMAN (7-323): 1.31e-18: 93.6: 27.95
+	Hs
		539799 IDE_HUMAN (1-1019): 0: 1084: 100.00		AINX_HUMAN (8-317): 2.29e-17: 89.4: 27.59
+	Hs
		422339 IDE_HUMAN (1-1019): 0: 1084: 100.00		NFM_HUMAN (8-333): 4.76e-14: 79.7: 26.21
+	Hs
		1055207 PREP_HUMAN (91-965): 1.14e-133: 431: 13.57		KRT81_HUMAN (6-313): 2.28e-64: 230: 21.34
+	Hs
		213957 PREP_HUMAN (91-965): 1.14e-133: 431: 13.57		KRT86_HUMAN (6-313): 2.99e-63: 226: 21.34
+	Hs
		213916 MPPB_HUMAN (49-493): 2.22e-113: 360: 16.81		KRT86_HUMAN (6-313): 2.99e-63: 226: 21.34
+	Hs
		264804 MPPB_HUMAN (49-493): 2.22e-113: 360: 16.81		K2C75_HUMAN (6-319): 4.7e-60: 219: 21.43
+	Hs
		213941 MPPA_HUMAN (6-482): 9.37e-106: 341: 14.54		KRT86_HUMAN (6-313): 2.99e-63: 226: 21.34
+	Hs
		264858 MPPB_HUMAN (49-493): 2.22e-113: 360: 16.81		MYH9_HUMAN (729-1459): 1.22e-24: 115: 10.48
+	Hs
		264832 MPPB_HUMAN (49-493): 2.22e-113: 360: 16.81		DESM_HUMAN (8-316): 2.1e-14: 79.7: 25.47
+	Hs
		569074 MPPA_HUMAN (6-482): 9.37e-106: 341: 14.54		DESM_HUMAN (8-316): 2.1e-14: 79.7: 25.47