Protein: M3K5
Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)

Gene: M3K5, MAP3K5
Organism: Homo sapiens
Interactions: 157
UniProt ID: Q99683

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0000287 - magnesium ion binding
GO:0002931 - response to ischemia
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1305583

M3K5
Mitogen-activated protein kinase kinase kinase 5

18

17

Small-scale

0.987

High

854738

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

9

18

Small-scale

0.969

High

805461

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

7

17

Small-scale

0.960

High

312810

M3K6
Mitogen-activated protein kinase kinase kinase 6

5

19

Small-scale

0.924

High

800998

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

5

19

Small-scale

0.920

High

1305585

CIB1
Calcium and integrin-binding protein 1

2

20

Small-scale

0.855

High

1305594

LATS2
Serine/threonine-protein kinase LATS2

2

19

Small-scale

0.831

High

374750

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

20

Small-scale

0.825

High

201408

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

16

Small-scale

0.815

High

758316

CDN1A
Cyclin-dependent kinase inhibitor 1

2

9

Small-scale

0.806

High

681998

AKT1
RAC-alpha serine/threonine-protein kinase

1

16

Small-scale

0.794

High

238435

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.785

High

495599

THIO
Thioredoxin

18

6

Small-scale

0.765

High

1020888

TRAF2
TNF receptor-associated factor 2

13

20

Small-scale

0.761

High

153163

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

2

17

Small-scale

0.754

High

265554

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

2

17

Small-scale

0.754

High

1305597

DAXX
Death domain-associated protein 6

7

3

Small-scale

0.744

High

1305607

TRAF6
TNF receptor-associated factor 6

7

20

Small-scale

0.741

High

673432

MPIP1
M-phase inducer phosphatase 1

1

2

Small-scale

0.740

High

927451

1433Z
14-3-3 protein zeta/delta

6

20

Small-scale

0.730

High

259776

PDCD6
Programmed cell death protein 6

1

9

Small-scale

0.724

High

673619

MPIP3
M-phase inducer phosphatase 3

1

2

Small-scale

0.724

High

682203

AKT2
RAC-beta serine/threonine-protein kinase

1

16

Small-scale

0.724

High

905034

1433G
14-3-3 protein gamma

5

20

Small-scale

0.716

High

1139210

DAB2P
Disabled homolog 2-interacting protein

5

12

Small-scale

0.708

High

181886

SOCS1
Suppressor of cytokine signaling 1

4

20

Small-scale

0.698

High

212499

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

14

High-throughput

0.691

High

678578

MK04
Mitogen-activated protein kinase 4

1

20

High-throughput

0.691

High

871467

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

19

High-throughput

0.691

High

909955

1433E
14-3-3 protein epsilon

4

20

Small-scale

0.681

High

982422

1433F
14-3-3 protein eta

4

20

Small-scale

0.676

High

827267

ARRB1
Beta-arrestin-1

3

10

Small-scale

0.670

High

1305604

TN13B
Tumor necrosis factor ligand superfamily member 13B

3

2

High-throughput

0.667

High

231694

KIF1B
Kinesin-like protein KIF1B

1

12

High-throughput

0.665

High

840804

DYN2
Dynamin-2

1

2

High-throughput

0.665

High

683661

1433B
14-3-3 protein beta/alpha

3

20

Small-scale

0.657

High

1290742

MCRS1
Microspherule protein 1

1

0

Small-scale

0.654

High

160734

AURKA
Aurora kinase A

1

17

High-throughput

0.647

High

515495

CDK4
Cyclin-dependent kinase 4

1

12

High-throughput

0.647

High

608098

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.647

High

616860

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.647

High

673099

CCND2
G1/S-specific cyclin-D2

1

5

High-throughput

0.647

High

960234

CDK6
Cyclin-dependent kinase 6

1

17

High-throughput

0.647

High

1079136

STK11
Serine/threonine-protein kinase STK11

1

17

High-throughput

0.647

High

1305588

GLIS2
Zinc finger protein GLIS2

1

12

High-throughput

0.647

High

686043

ARRB2
Beta-arrestin-2

3

10

Small-scale

0.646

High

647219

1433T
14-3-3 protein theta

3

20

Small-scale

0.642

High

129590

TRAF5
TNF receptor-associated factor 5

3

20

Small-scale

0.640

High

1305602

CHIP
E3 ubiquitin-protein ligase CHIP

3

14

Small-scale

0.640

High

599717

TNAP3
Tumor necrosis factor alpha-induced protein 3

2

14

Small-scale

0.634

High

808239

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

20

Small-scale

0.629

High

1305603

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

2

20

Small-scale

0.624

High

395567

A4
Amyloid-beta precursor protein

2

13

Small-scale

0.621

High

149212

CTRO
Citron Rho-interacting kinase

1

19

High-throughput

0.618

High

181637

CFLAR
CASP8 and FADD-like apoptosis regulator

1

7

Small-scale

0.618

High

432196

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

438465

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

585538

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

20

Small-scale

0.618

High

926750

CANB1
Calcineurin subunit B type 1

1

11

Small-scale

0.618

High

1044090

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

20

Small-scale

0.618

High

1082620

MK14
Mitogen-activated protein kinase 14

1

20

Small-scale

0.618

High

1259410

DUS19
Dual specificity protein phosphatase 19

1

6

Small-scale

0.618

High

1305601

ALK
ALK tyrosine kinase receptor

1

20

Small-scale

0.618

High

1282211

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

1

Small-scale

0.612

High

1012427

Q0VDC6
peptidylprolyl isomerase

1

11

High-throughput

0.594

High

986021

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

7

Small-scale

0.589

High

451109

GSTM1
Glutathione S-transferase Mu 1

2

4

Small-scale

0.584

High

1023778

TRAF1
TNF receptor-associated factor 1

2

17

Small-scale

0.584

High

1024746

TRAF3
TNF receptor-associated factor 3

2

20

Small-scale

0.584

High

1304224

PARK7
Parkinson disease protein 7

2

1

Small-scale

0.584

High

1305598

FBW1B
F-box/WD repeat-containing protein 11

2

19

Small-scale

0.584

High

1216690

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

12

Small-scale

0.578

High

1256666

GEMI5
Gem-associated protein 5

1

5

Small-scale

0.578

High

1305586

ANM1
Protein arginine N-methyltransferase 1

1

2

Small-scale

0.578

High

202776

TPD54
Tumor protein D54

1

1

Small-scale

0.573

High

258871

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

1

1

Small-scale

0.561

High

858663

PPP5
Serine/threonine-protein phosphatase 5

1

20

Small-scale

0.561

High

928178

SUMO1
Small ubiquitin-related modifier 1

1

6

Small-scale

0.561

High

930367

UBC9
SUMO-conjugating enzyme UBC9

1

16

Small-scale

0.561

High

1273713

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

16

Small-scale

0.561

High

1305606

STRAP
Serine-threonine kinase receptor-associated protein

1

6

Small-scale

0.561

High

1084879

SMN
Survival motor neuron protein

1

2

Small-scale

0.543

High

513889

DMD
Dystrophin

1

20

High-throughput

0.541

High

999014

EP300
Histone acetyltransferase p300

1

18

High-throughput

0.541

High

1270773

CBP
CREB-binding protein

1

17

High-throughput

0.541

High

1261694

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

1

0

Small-scale

0.537

High

1284779

EFMT3
EEF1A lysine methyltransferase 3

1

7

High-throughput

0.536

High

1300831

NACC1
Nucleus accumbens-associated protein 1

1

19

High-throughput

0.536

High

1305589

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

1305591

RABE2
Rab GTPase-binding effector protein 2

1

20

High-throughput

0.536

High

1305592

EGLN3
Prolyl hydroxylase EGLN3

1

6

High-throughput

0.536

High

1305595

ATD3A
ATPase family AAA domain-containing protein 3A

1

9

High-throughput

0.536

High

632369

TNR6
Tumor necrosis factor receptor superfamily member 6

1

4

Small-scale

0.515

High

878356

NH2L1
NHP2-like protein 1

1

3

High-throughput

0.515

High

1256749

FBF1
Fas-binding factor 1

1

20

High-throughput

0.515

High

204034

HTRA2
Serine protease HTRA2, mitochondrial

1

4

High-throughput

0.515

High

358873

CRYAA
Alpha-crystallin A chain

1

9

High-throughput

0.515

High

388683

HSPB1
Heat shock protein beta-1

1

9

High-throughput

0.515

High

780769

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

12

High-throughput

0.515

High

791904

HD
Huntingtin

1

8

High-throughput

0.515

High

871752

HSP72
Heat shock-related 70 kDa protein 2

1

20

High-throughput

0.515

High

893459

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

5

High-throughput

0.515

High

1051656

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

2

High-throughput

0.515

High

1271943

KLK6
Kallikrein-6

1

4

High-throughput

0.515

High

1305596

VPS29
Vacuolar protein sorting-associated protein 29

1

1

High-throughput

0.515

High

253169

HSF2B
Heat shock factor 2-binding protein

1

0

High-throughput

0.513

High

154046

TERT
Telomerase reverse transcriptase

1

1

High-throughput

0.501

High

362100

MBP
Myelin basic protein

1

7

Small-scale

0.501

High

719596

MERL
Merlin

1

17

High-throughput

0.501

High

790858

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

17

High-throughput

0.501

High

1075246

TEAD2
Transcriptional enhancer factor TEF-4

1

2

High-throughput

0.501

High

1299607

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

20

High-throughput

0.501

High

1305600

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.501

High

588932

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.493

High

1251982

GDAP1
Ganglioside-induced differentiation-associated protein 1

1

0

High-throughput

0.493

High

147444

SOCS3
Suppressor of cytokine signaling 3

1

20

Small-scale

0.479

High

177716

BIRC5
Baculoviral IAP repeat-containing protein 5

1

11

Small-scale

0.479

High

325342

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

5

Small-scale

0.479

High

382121

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

4

Small-scale

0.479

High

448379

GSTP1
Glutathione S-transferase P

1

4

Small-scale

0.479

High

545897

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

11

Small-scale

0.479

High

573057

PRS6A
26S proteasome regulatory subunit 6A

1

9

Small-scale

0.479

High

655451

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

13

Small-scale

0.479

High

714376

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.479

High

728549

GLRX1
Glutaredoxin-1

1

1

Small-scale

0.479

High

730340

PRS7
26S proteasome regulatory subunit 7

1

3

Small-scale

0.479

High

798742

PRS6B
26S proteasome regulatory subunit 6B

1

3

Small-scale

0.479

High

814518

SYQ
Glutamine--tRNA ligase

1

3

Small-scale

0.479

High

871059

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

7

Small-scale

0.479

High

906908

PRS4
26S proteasome regulatory subunit 4

1

3

Small-scale

0.479

High

907136

PRS8
26S proteasome regulatory subunit 8

1

4

Small-scale

0.479

High

974734

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

8

Small-scale

0.479

High

975313

KMT2A
Histone-lysine N-methyltransferase 2A

1

13

Small-scale

0.479

High

1036332

BIRC2
Baculoviral IAP repeat-containing protein 2

1

18

Small-scale

0.479

High

1042372

CUL3
Cullin-3

1

13

High-throughput

0.479

High

1043184

CUL4A
Cullin-4A

1

13

High-throughput

0.479

High

1053428

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

7

Small-scale

0.479

High

1088508

TPD53
Tumor protein D53

1

1

Small-scale

0.479

High

1255669

RBCC1
RB1-inducible coiled-coil protein 1

1

20

Small-scale

0.479

High

1291553

OTUB1
Ubiquitin thioesterase OTUB1

1

1

Small-scale

0.479

High

1305587

TRAF4
TNF receptor-associated factor 4

1

20

Small-scale

0.479

High

1305590

TOLIP
Toll-interacting protein

1

3

Small-scale

0.479

High

1305599

RN150
RING finger protein 150

1

3

Small-scale

0.479

High

1305605

FBW1A
F-box/WD repeat-containing protein 1A

1

20

Small-scale

0.479

High

660682

GRN
Progranulin

1

1

High-throughput

0.470

High

1048452

LRP8
Low-density lipoprotein receptor-related protein 8

1

2

High-throughput

0.470

High

1221987

IFT20
Intraflagellar transport protein 20 homolog

1

0

Small-scale

0.458

High

1305593

ABC3G
DNA dC->dU-editing enzyme APOBEC-3G

1

0

Small-scale

0.458

High

684290

1433S
14-3-3 protein sigma

1

20

Small-scale

0.457

High

347696

MYC
Myc proto-oncogene protein

1

18

High-throughput

0.445

High

497492

TAU
Microtubule-associated protein tau

1

20

Small-scale

0.445

High

1067110

BRD3
Bromodomain-containing protein 3

1

11

High-throughput

0.437

High

1163028

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

18

Small-scale

0.437

High

1293795

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

4

Small-scale

0.437

High

1305584

THIOM
Thioredoxin, mitochondrial

1

7

Small-scale

0.437

High

262554

TULP3
Tubby-related protein 3

1

0

High-throughput

0.282

High


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Last updated: 15 Jul 2024