HitPredict

Interactor 1: PHO85 (P17157)
Cyclin-dependent protein kinase PHO85 (EC 2.7.11.22) (Negative regulator of the PHO system) (Serine/threonine-protein kinase PHO85)
Gene: PHO85

Interactor 2: CCL1 (P37366)
Cyclin CCL1
Gene: CCL1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.740

Property	Details
Experiments	9032248
Identification Methods	affinity chromatography technology, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Cyclin_C_2~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 305 Sc			1 393
+	Hs
		625350 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		CCNA1_HUMAN (57-333): 5.69e-82: 260: 15.60
+	Hs
		538471 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		CCNB1_HUMAN (40-348): 4.3e-80: 254: 13.38
+	Hs
		303829 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		CCNB2_HUMAN (10-349): 3.04e-79: 250: 12.09
+	Hs
		538521 CDK3_HUMAN (4-304): 1.01e-141: 403: 52.65		CCNB1_HUMAN (40-348): 4.3e-80: 254: 13.38
+	Hs
		590125 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		CCNA2_HUMAN (9-332): 3.36e-73: 236: 15.65
+	Hs
		590162 CDK3_HUMAN (4-304): 1.01e-141: 403: 52.65		CCNA2_HUMAN (9-332): 3.36e-73: 236: 15.65
+	Hs
		624539 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		CCNE1_HUMAN (19-344): 1.49e-69: 226: 12.87
+	Mm
		956329 CDK2_MOUSE (4-303): 1.15e-135: 389: 47.28		CCNA1_MOUSE (38-335): 1.68e-77: 247: 13.86
+	Rn
		70081 Q6P751_RAT (4-303): 1.28e-144: 410: 54.82		B1WC54_RAT (9-347): 3.03e-69: 225: 10.96
+	Xl
		193809 CDK2_XENLA (4-304): 1.91e-143: 407: 55.30		CCNE3_XENLA (9-341): 7.64e-69: 224: 12.91
+	Mm
		851183 CDK2_MOUSE (4-303): 1.15e-135: 389: 47.28		CCNA2_MOUSE (1-333): 2.23e-75: 241: 14.52
+	Hs
		624573 CDK3_HUMAN (4-304): 1.01e-141: 403: 52.65		CCNE1_HUMAN (19-344): 1.49e-69: 226: 12.87
+	Hs
		625251 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		CCNH_HUMAN (48-392): 5.2e-65: 211: 24.51
+	Sc
		565686 PHO85_YEAST (1-305): 6.32e-140: 398: 100.00		SSN8_YEAST (48-362): 1.97e-68: 220: 20.62
+	Rn
		981205 Q6P751_RAT (4-303): 1.28e-144: 410: 54.82		CCND2_RAT (71-329): 1.16e-63: 207: 12.59
+	Hs
		624422 CDK3_HUMAN (4-304): 1.01e-141: 403: 52.65		CCNC_HUMAN (49-361): 4.67e-66: 213: 20.54
+	Hs
		851197 CDK3_HUMAN (4-304): 1.01e-141: 403: 52.65		CCNH_HUMAN (48-392): 5.2e-65: 211: 24.51
+	Hs
		625155 CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82		CCND2_HUMAN (71-334): 1.44e-61: 201: 12.32
+	Mm
		673122 CDK2_MOUSE (4-303): 1.15e-135: 389: 47.28		CCND2_MOUSE (71-328): 1.33e-63: 206: 12.27
+	Hs
		960107 CDK3_HUMAN (4-304): 1.01e-141: 403: 52.65		CCNQ_HUMAN (121-312): 3.94e-54: 181: 17.70