Protein: ACM3
Muscarinic acetylcholine receptor M3

Gene: ACM3, CHRM3
Organism: Homo sapiens
Interactions: 81
UniProt ID: P20309

Gene Ontology (top 5):
GO:0004435 - phosphatidylinositol-4,5-bisphosphate phospholipase C activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006939 - smooth muscle contraction
GO:0006940 - regulation of smooth muscle contraction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

630149

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

10

High-throughput

0.698

High

477153

ACM5
Muscarinic acetylcholine receptor M5

1

17

Small-scale

0.665

High

168816

PLD2
Phospholipase D2

2

2

High-throughput

0.628

High

630141

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

2

8

High-throughput

0.628

High

630155

CAV1
Caveolin-1

2

5

High-throughput

0.628

High

630158

AT1A4
Sodium/potassium-transporting ATPase subunit alpha-4

2

9

High-throughput

0.628

High

630168

LRP10
Low-density lipoprotein receptor-related protein 10

2

3

High-throughput

0.628

High

630174

ATLA2
Atlastin-2

2

1

High-throughput

0.628

High

630184

EXOC2
Exocyst complex component 2

2

2

High-throughput

0.628

High

630194

STX18
Syntaxin-18

2

1

High-throughput

0.628

High

630203

S4A7
Sodium bicarbonate cotransporter 3

2

3

High-throughput

0.628

High

630146

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.618

High

630143

KC1A
Casein kinase I isoform alpha

1

0

Small-scale

0.614

High

630175

PIGX
GPI alpha-1,4-mannosyltransferase I, stabilizing subunit

2

0

High-throughput

0.602

High

317792

LTN1
E3 ubiquitin-protein ligase listerin

2

1

High-throughput

0.574

High

318109

IPO13
Importin-13

2

11

High-throughput

0.574

High

320533

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

2

2

High-throughput

0.574

High

630147

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

2

2

High-throughput

0.574

High

630150

TBA4A
Tubulin alpha-4A chain

2

4

High-throughput

0.574

High

630159

STAR3
StAR-related lipid transfer protein 3

2

1

High-throughput

0.574

High

630160

TBB8
Tubulin beta-8 chain

2

4

High-throughput

0.574

High

630163

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

2

2

High-throughput

0.574

High

630167

DYM
Dymeclin

2

3

High-throughput

0.574

High

630169

HEAT3
HEAT repeat-containing protein 3

2

2

High-throughput

0.574

High

630176

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

2

3

High-throughput

0.574

High

630180

HOOK2
Protein Hook homolog 2

2

1

High-throughput

0.574

High

630186

IPO9
Importin-9

2

10

High-throughput

0.574

High

630190

GTPB2
GTP-binding protein 2

2

5

High-throughput

0.574

High

630193

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

2

4

High-throughput

0.574

High

630148

ARF6
ADP-ribosylation factor 6

1

3

Small-scale

0.561

High

630152

ARF1
ADP-ribosylation factor 1

1

3

Small-scale

0.561

High

630142

PI4KA
Phosphatidylinositol 4-kinase alpha

2

5

High-throughput

0.552

High

630138

BASI
Basigin

1

2

High-throughput

0.541

High

630156

TAP1
Antigen peptide transporter 1

1

2

High-throughput

0.541

High

630191

YIPF3
Protein YIPF3

1

6

High-throughput

0.541

High

251192

RNBP6
Ran-binding protein 6

1

5

High-throughput

0.536

High

565551

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

9

High-throughput

0.536

High

630139

VGFR3
Vascular endothelial growth factor receptor 3

1

3

High-throughput

0.536

High

630151

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

High-throughput

0.536

High

630157

TBB3
Tubulin beta-3 chain

1

4

High-throughput

0.536

High

630165

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

1

1

High-throughput

0.536

High

630166

CERS6
Ceramide synthase 6

1

13

High-throughput

0.536

High

630188

YIPF4
Protein YIPF4

1

5

High-throughput

0.536

High

630161

Q4LE69
Phosphatidylinositol 4-kinase alpha

2

4

High-throughput

0.533

High

630189

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.518

High

630181

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.513

High

630192

JPH1
Junctophilin-1

1

0

High-throughput

0.513

High

630154

SET
Protein SET

1

1

Small-scale

0.512

High

630145

RGS7
Regulator of G-protein signaling 7

1

12

Small-scale

0.501

High

630185

JKIP1
Janus kinase and microtubule-interacting protein 1

1

3

High-throughput

0.494

High

231676

PEX1
Peroxisomal ATPase PEX1

1

1

High-throughput

0.489

High

273158

CAND2
Cullin-associated NEDD8-dissociated protein 2

1

5

High-throughput

0.489

High

334680

IPO7
Importin-7

1

10

High-throughput

0.489

High

630173

ARL10
ADP-ribosylation factor-like protein 10

1

8

High-throughput

0.489

High

630177

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

6

High-throughput

0.489

High

630178

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

1

High-throughput

0.489

High

630179

F241B
Protein FAM241B

1

1

High-throughput

0.489

High

630200

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

2

High-throughput

0.489

High

630140

SYUA
Alpha-synuclein

1

5

High-throughput

0.481

High

630144

RGS4
Regulator of G-protein signaling 4

1

13

Small-scale

0.479

High

630153

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

High-throughput

0.479

High

630187

NEB2
Neurabin-2

1

20

Small-scale

0.479

High

68009

P121C
Nuclear envelope pore membrane protein POM 121C

1

2

High-throughput

0.457

High

630172

NALCN
Sodium leak channel NALCN

1

1

Small-scale

0.445

High

76095

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

1

High-throughput

0.439

High

630164

GASP1
G-protein coupled receptor-associated sorting protein 1

1

14

Small-scale

0.437

High

208016

TTI1
TELO2-interacting protein 1 homolog

2

0

High-throughput

0.328

High

630195

TRM7
tRNA

2

0

High-throughput

0.328

High

630197

GPN3
GPN-loop GTPase 3

2

0

High-throughput

0.328

High

630198

NOCT
Nocturnin

2

0

High-throughput

0.328

High

630201

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

2

0

High-throughput

0.328

High

335779

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.282

High

447673

TPM3
Tropomyosin alpha-3 chain

1

0

High-throughput

0.282

High

630162

CC184
Coiled-coil domain-containing protein 184

1

0

High-throughput

0.282

High

630170

COMD7
COMM domain-containing protein 7

1

0

High-throughput

0.282

High

630182

SGSM3
Small G protein signaling modulator 3

1

0

High-throughput

0.282

High

630196

SEPT3
Neuronal-specific septin-3

1

0

High-throughput

0.282

High

630199

MAGD2
Melanoma-associated antigen D2

1

0

High-throughput

0.282

High

630171

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.279

Low

630183

SYNM
Asparaginyl-tRNA synthetase

1

0

High-throughput

0.279

Low

630202

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025