HitPredict

Interactor 1: PRS6A (P17980)
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Gene: PSMC3

Interactor 2: UBP14 (P54578)
Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)
Gene: USP14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	30425250, 31901637, 31740976, 19615732, 36528617
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Prot_ATP_ID_OB~UCH
Common GO terms	GO:0000502 - proteasome complex GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 439 Hs			1 494
+	Hs
		870728 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		UBP14_HUMAN (1-494): 7.04e-147: 431: 100.00
+	Hs
		870729 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		UBP14_HUMAN (1-494): 7.04e-147: 431: 100.00
+	Hs
		798619 PRS6B_HUMAN (8-438): 1.04e-118: 354: 37.59		UBP14_HUMAN (1-494): 7.04e-147: 431: 100.00
+	Sp
		144491 PRS6A_SCHPO (27-439): 1.42e-129: 382: 71.74		UBP6_SCHPO (3-485): 1.47e-112: 342: 36.31
+	Hs
		870712 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		UBP14_HUMAN (1-494): 7.04e-147: 431: 100.00
+	Hs
		907177 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		UBP36_HUMAN (65-482): 3.73e-90: 299: 17.54
+	Dm
		186175 PRS8_DROME (47-438): 5.38e-119: 354: 41.48		X2JLM6_DROME (31-482): 6.68e-90: 287: 19.40
+	Sc
		703668 PRS6A_YEAST (20-439): 2.06e-117: 351: 68.08		UBP6_YEAST (4-481): 1.15e-88: 282: 30.10
+	Sc
		771716 PRS4_YEAST (122-431): 4.87e-102: 312: 50.65		UBP6_YEAST (4-481): 1.15e-88: 282: 30.10
+	Hs
		1239613 AFG2A_HUMAN (182-435): 3.65e-68: 234: 35.32		UBP36_HUMAN (65-482): 3.73e-90: 299: 17.54
+	Sc
		703690 PRS6A_YEAST (20-439): 2.06e-117: 351: 68.08		UBP8_YEAST (105-485): 5.83e-38: 146: 20.51
+	Sc
		771721 PRS4_YEAST (122-431): 4.87e-102: 312: 50.65		UBP8_YEAST (105-485): 5.83e-38: 146: 20.51
+	Zm
		28550 B8A0A6_MAIZE (44-432): 4.84e-107: 325: 44.78		A0A1D6JSI9_MAIZE (93-456): 4.4e-30: 126: 18.60
+	Sc
		636674 CDC48_YEAST (144-419): 9.98e-80: 265: 37.32		UBP8_YEAST (105-485): 5.83e-38: 146: 20.51