HitPredict - High confidence protein-protein interactions

Interactor 1: ATF6A (P18850)
Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha]
Gene: ATF6

Interactor 2: ATF6A (P18850)
Cyclic AMP-dependent transcription factor ATF-6 alpha (cAMP-dependent transcription factor ATF-6 alpha) (Activating transcription factor 6 alpha) (ATF6-alpha) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 alpha]
Gene: ATF6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

Property	Details
Experiments	11158310, 23661758, 20102225, 25609649, 12805554
Identification Methods	two hybrid, fluorescent resonance energy transfer, peptide array, tandem affinity purification
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	bZIP_1~bZIP_1
Common GO terms	GO:0000139 - Golgi membrane GO:0000785 - chromatin GO:0000976 - transcription cis-regulatory region binding GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding and 29 others more... GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001654 - eye development GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005635 - nuclear envelope GO:0005654 - nucleoplasm GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0006357 - regulation of transcription by RNA polymerase II GO:0006457 - protein folding GO:0007165 - signal transduction GO:0007601 - visual perception GO:0010508 - positive regulation of autophagy GO:0016020 - membrane GO:0019899 - enzyme binding GO:0030968 - endoplasmic reticulum unfolded protein response GO:0034976 - response to endoplasmic reticulum stress GO:0036500 - ATF6-mediated unfolded protein response GO:0036503 - ERAD pathway GO:0043065 - positive regulation of apoptotic process GO:0043565 - sequence-specific DNA binding GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046982 - protein heterodimerization activity GO:0090575 - RNA polymerase II transcription regulator complex GO:1903893 - positive regulation of ATF6-mediated unfolded protein response GO:1990837 - sequence-specific double-stranded DNA binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1	670
Hs

1	670

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Last updated: 15 Jul 2024