HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: MTR1A (P48039)
Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)
Gene: MTNR1A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.620

Property	Details
Experiments	26514267, 17215244
Identification Methods	pull down, two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 350
+	Hs
		428914 FLNA_HUMAN (1-2647): 0: 2776: 100.00		ADRB2_HUMAN (3-334): 5.8e-74: 236: 19.73
+	Hs
		815890 Q60FE5_HUMAN (28-2647): 0: 2767: 100.00		MTR1A_HUMAN (1-350): 1.56e-75: 238: 100.00
+	Hs
		597983 FLNA_HUMAN (1-2647): 0: 2776: 100.00		OPRM_HUMAN (2-342): 1.58e-68: 221: 22.54
+	Hs
		598007 FLNA_HUMAN (1-2647): 0: 2776: 100.00		MTR1B_HUMAN (21-337): 3.11e-68: 219: 63.09
+	Hs
		825709 Q60FE5_HUMAN (28-2647): 0: 2767: 100.00		MTR1B_HUMAN (21-337): 3.11e-68: 219: 63.09
+	Hs
		537253 FLNA_HUMAN (1-2647): 0: 2776: 100.00		DRD2_HUMAN (10-228): 8.22e-21: 94.7: 30.63
+	Hs
		723009 FLNC_HUMAN (32-2647): 0: 1432: 35.96		ADA1B_HUMAN (3-349): 1.18e-74: 241: 20.67
+	Hs
		722936 FLNC_HUMAN (32-2647): 0: 1432: 35.96		ADA1A_HUMAN (1-322): 4.59e-73: 235: 20.89
+	Hs
		626688 FLNC_HUMAN (32-2647): 0: 1432: 35.96		ADA1D_HUMAN (7-306): 1.08e-69: 229: 21.28
+	Hs
		521496 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		MTR1A_HUMAN (1-350): 1.56e-75: 238: 100.00
+	Hs
		656944 ACTN2_HUMAN (6-459): 1.76e-121: 410: 23.62		5HT1B_HUMAN (3-316): 1.14e-65: 214: 20.76
+	Hs
		521497 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		MTR1B_HUMAN (21-337): 3.11e-68: 219: 63.09