HitPredict

Interactor 1: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Interactor 2: WASP (P42768)
Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp)
Gene: WAS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14521508
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras
Common GO terms	GO:0005884 - actin filament GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 205 Hs			1 502
+	Hs
		133689 RHOJ_HUMAN (9-204): 1.18e-108: 311: 79.59		WASL_HUMAN (15-311): 1.14e-115: 352: 47.67
+	Hs
		842665 RHOJ_HUMAN (9-204): 1.18e-108: 311: 79.59		WASP_HUMAN (1-487): 7.13e-99: 308: 100.00
+	Hs
		133636 RHOQ_HUMAN (1-205): 3.47e-83: 247: 100.00		WASL_HUMAN (15-311): 1.14e-115: 352: 47.67
+	Hs
		842636 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		WASP_HUMAN (1-487): 7.13e-99: 308: 100.00
+	Hs
		580913 RAC2_HUMAN (10-196): 9.52e-77: 230: 62.03		WASP_HUMAN (1-487): 7.13e-99: 308: 100.00
+	Hs
		842630 RAC3_HUMAN (10-183): 3.69e-76: 228: 66.67		WASP_HUMAN (1-487): 7.13e-99: 308: 100.00
+	Dm
		828020 RAC1_DROME (10-195): 5.51e-77: 230: 63.98		Q9VAT0_DROME (13-398): 5.52e-75: 247: 34.33
+	Ce
		1050326 CDC42_CAEEL (10-193): 3.52e-91: 266: 67.94		Q17795_CAEEL (13-498): 7.82e-60: 209: 21.66
+	Dm
		828053 CDC42_DROME (9-193): 3.15e-75: 226: 69.19		Q9VAT0_DROME (13-398): 5.52e-75: 247: 34.33
+	Ce
		1041909 RAC1_CAEEL (10-193): 1.86e-78: 234: 60.87		Q17795_CAEEL (13-498): 7.82e-60: 209: 21.66
+	Ce
		110131 G5EBV3_CAEEL (1-193): 4.42e-75: 226: 53.37		Q17795_CAEEL (13-498): 7.82e-60: 209: 21.66
+	Hs
		319077 RHOJ_HUMAN (9-204): 1.18e-108: 311: 79.59		K0754_HUMAN (242-499): 3.14e-10: 65.1: 13.11
+	Sc
		618359 CDC42_YEAST (10-185): 5.83e-85: 251: 66.48		STE20_YEAST (152-471): 6.88e-21: 98.6: 14.84
+	Hs
		896719 RHOA_HUMAN (1-201): 1.72e-76: 229: 49.75		DYN2_HUMAN (244-438): 1.34e-24: 109: 17.54
+	Hs
		319060 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		K0754_HUMAN (242-499): 3.14e-10: 65.1: 13.11
+	Hs
		208121 RHOA_HUMAN (1-201): 1.72e-76: 229: 49.75		PLXB1_HUMAN (307-500): 2.98e-12: 71.5: 23.50
+	Hs
		319064 RHOG_HUMAN (9-199): 1.71e-77: 231: 54.97		K0754_HUMAN (242-499): 3.14e-10: 65.1: 13.11
+	Hs
		319049 RAC2_HUMAN (10-196): 9.52e-77: 230: 62.03		K0754_HUMAN (242-499): 3.14e-10: 65.1: 13.11
+	Hs
		319057 RHOA_HUMAN (1-201): 1.72e-76: 229: 49.75		K0754_HUMAN (242-499): 3.14e-10: 65.1: 13.11
+	Hs
		319056 RAC3_HUMAN (10-183): 3.69e-76: 228: 66.67		K0754_HUMAN (242-499): 3.14e-10: 65.1: 13.11