HitPredict

Interactor 1: VDAC1 (P21796)
Voltage-dependent anion-selective channel protein 1 (VDAC-1) (hVDAC1) (Outer mitochondrial membrane protein porin 1) (Plasmalemmal porin) (Porin 31HL) (Porin 31HM)
Gene: VDAC1

Interactor 2: FKBP8 (Q14318)
Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)
Gene: FKBP8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0006915 - apoptotic process GO:0016020 - membrane GO:0031966 - mitochondrial membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 283 Hs			1 412
+	Hs
		799991 VDAC2_HUMAN (1-283): 4.13e-118: 342: 74.56		FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00
+	Hs
		1053259 VDAC3_HUMAN (1-283): 1.29e-105: 310: 67.49		FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00
+	Hs
		330671 TOM40_HUMAN (4-279): 5.43e-60: 196: 12.46		FKBP8_HUMAN (1-412): 5.79e-102: 310: 100.00
+	Hs
		601143 VDAC1_HUMAN (1-283): 1.37e-110: 322: 100.00		STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00
+	Hs
		330657 TOM40_HUMAN (4-279): 5.43e-60: 196: 12.46		FKB1A_HUMAN (101-204): 1.72e-35: 128: 32.41