HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	16729043
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1342 Hs			1 450
+	Hs
		337346 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83
+	Hs
		522774 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		SRC_HUMAN (12-442): 8.48e-171: 491: 39.33
+	Hs
		433253 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		YES_HUMAN (12-442): 5.99e-170: 490: 37.30
+	Hs
		411594 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LCK_HUMAN (5-443): 1.95e-168: 485: 38.55
+	Hs
		601837 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		ABL2_HUMAN (4-443): 1.63e-160: 485: 39.33
+	Hs
		442779 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		HCK_HUMAN (3-445): 6.38e-167: 481: 36.32
+	Hs
		454797 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		FGR_HUMAN (12-442): 4.47e-165: 476: 38.43
+	Hs
		601834 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		MATK_HUMAN (7-440): 2.57e-161: 466: 53.79
+	Hs
		433575 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		LYN_HUMAN (4-445): 3.75e-160: 463: 37.12
+	Hs
		601836 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TXK_HUMAN (10-443): 4.44e-159: 461: 36.75
+	Hs
		601856 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		BLK_HUMAN (8-445): 3.88e-159: 461: 37.03
+	Hs
		601835 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		TEC_HUMAN (8-450): 6.4e-150: 442: 36.96
+	Hs
		601919 ERBB3_HUMAN (1-1342): 0: 1388: 100.00		PTK6_HUMAN (11-447): 3.62e-149: 433: 35.41
+	Hs
		337480 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83
+	Hs
		412202 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		FYN_HUMAN (12-442): 1.26e-170: 491: 36.77
+	Hs
		433359 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		YES_HUMAN (12-442): 5.99e-170: 490: 37.30
+	Hs
		411729 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		LCK_HUMAN (5-443): 1.95e-168: 485: 38.55
+	Hs
		442833 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		HCK_HUMAN (3-445): 6.38e-167: 481: 36.32
+	Hs
		454834 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		FGR_HUMAN (12-442): 4.47e-165: 476: 38.43
+	Hs
		433770 ERBB4_HUMAN (1-1162): 0: 1152: 50.94		LYN_HUMAN (4-445): 3.75e-160: 463: 37.12