HitPredict

Interactor 1: UBA1 (P22515)
Ubiquitin-activating enzyme E1 1 (EC 6.2.1.45)
Gene: UBA1

Interactor 2: UBC7 (Q02159)
Ubiquitin-conjugating enzyme E2 7 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 7) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-18 kDa) (Ubiquitin-protein ligase)
Gene: UBC7

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.845

Property	Details
Experiments	9172777, 18321851, 33015833
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1024 Sc			1 165
+	Sc
		549788 UBA1_YEAST (1-1024): 0: 1089: 100.00		UBC4_YEAST (1-163): 5.02e-72: 215: 35.58
+	Sp
		116506 UBA1_SCHPO (1-1024): 0: 1038: 58.29		UBC7_SCHPO (1-165): 5.13e-71: 213: 61.45
+	Sp
		293848 UBA1_SCHPO (1-1024): 0: 1038: 58.29		UBC4_SCHPO (4-163): 3.38e-71: 212: 36.25
+	Sp
		293847 UBA1_SCHPO (1-1024): 0: 1038: 58.29		UBC2_SCHPO (1-162): 5.18e-70: 210: 38.89
+	Sc
		539443 UBA1_YEAST (1-1024): 0: 1089: 100.00		UBC3_YEAST (4-162): 1.54e-35: 126: 41.36
+	Sc
		410211 UBA1_YEAST (1-1024): 0: 1089: 100.00		UBC2_YEAST (1-162): 1.26e-36: 125: 37.65
+	Sp
		293852 UBA1_SCHPO (1-1024): 0: 1038: 58.29		UBC15_SCHPO (2-151): 7.44e-47: 152: 54.67
+	Hs
		48104 UBA6_HUMAN (2-1024): 0: 966: 40.81		UB2D1_HUMAN (4-164): 7.38e-73: 217: 36.65
+	Hs
		48107 UBA6_HUMAN (2-1024): 0: 966: 40.81		UB2D2_HUMAN (4-164): 1.2e-72: 216: 36.03
+	Hs
		48105 UBA6_HUMAN (2-1024): 0: 966: 40.81		UB2G2_HUMAN (1-165): 1.05e-71: 214: 62.42
+	Hs
		48106 UBA6_HUMAN (2-1024): 0: 966: 40.81		UB2D3_HUMAN (4-164): 2.23e-71: 213: 36.03
+	Sc
		854609 UBA2_YEAST (25-426): 1.8e-67: 240: 16.18		UBC7_YEAST (1-165): 1.28e-71: 214: 100.00
+	Hs
		930429 SAE2_HUMAN (24-413): 8.43e-82: 280: 15.72		UBC9_HUMAN (1-156): 1.04e-30: 110: 38.13
+	Dm
		1181395 Q7KUA4_DROME (25-417): 2.89e-76: 267: 13.57		Q7KNM2_DROME (1-156): 6.35e-31: 110: 37.50
+	Hs
		919796 UBA3_HUMAN (790-994): 5.83e-41: 159: 14.55		UB2D2_HUMAN (4-164): 1.2e-72: 216: 36.03
+	Hs
		607026 UBA1_HUMAN (393-622): 1.44e-27: 123: 17.75		UB2D1_HUMAN (4-164): 7.38e-73: 217: 36.65
+	Hs
		607023 UBA1_HUMAN (393-622): 1.44e-27: 123: 17.75		UBE2A_HUMAN (1-162): 4.5e-68: 205: 38.27
+	Hs
		930427 SAE1_HUMAN (409-706): 1.78e-61: 215: 20.46		UBC9_HUMAN (1-156): 1.04e-30: 110: 38.13
+	Hs
		607022 UBA1_HUMAN (393-622): 1.44e-27: 123: 17.75		UB2R1_HUMAN (4-145): 1.59e-40: 137: 49.30
+	Dm
		1181392 Q7KSM5_DROME (408-574): 6.88e-38: 147: 22.16		Q7KNM2_DROME (1-156): 6.35e-31: 110: 37.50