HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: ABI1 (Q8IZP0)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.534

Property	Details
Experiments	17395426
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0017124 - SH3 domain binding GO:0030426 - growth cone GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 508
+	Mm
		82737 B9EKI5_MOUSE (23-901): 0: 799: 47.22		ABI1_MOUSE (1-508): 1.42e-122: 369: 91.93
+	Hs
		1027616 CBLB_HUMAN (23-901): 0: 793: 46.65		ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00
+	Hs
		610400 CBL_HUMAN (1-906): 0: 917: 100.00		SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72
+	Hs
		610532 CBL_HUMAN (1-906): 0: 917: 100.00		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Hs
		610379 CBL_HUMAN (1-906): 0: 917: 100.00		MYO1E_HUMAN (305-503): 2.96e-27: 118: 22.67
+	Hs
		610517 CBL_HUMAN (1-906): 0: 917: 100.00		ITSN2_HUMAN (44-508): 6.18e-18: 89.8: 11.98
+	Hs
		610526 CBL_HUMAN (1-906): 0: 917: 100.00		DBNL_HUMAN (316-503): 2.32e-17: 86.1: 20.53
+	Hs
		235473 CBL_HUMAN (1-906): 0: 917: 100.00		VINEX_HUMAN (229-504): 5.02e-15: 79.8: 15.58
+	Hs
		610540 CBL_HUMAN (1-906): 0: 917: 100.00		CD2AP_HUMAN (451-508): 2.26e-14: 77.9: 40.68
+	Mm
		610657 CBL_MOUSE (1-906): 0: 888: 91.59		ITSN2_MOUSE (41-508): 1.34e-20: 97.9: 12.82
+	Hs
		610415 CBL_HUMAN (1-906): 0: 917: 100.00		ITSN1_HUMAN (399-504): 1.82e-09: 62.5: 20.35
+	Mm
		610656 CBL_MOUSE (1-906): 0: 888: 91.59		ITSN1_MOUSE (327-504): 1.8e-11: 69: 14.60
+	Hs
		1027630 CBLB_HUMAN (23-901): 0: 793: 46.65		ASAP1_HUMAN (107-505): 8.23e-33: 135: 16.83
+	Mm
		1112081 CBLB_MOUSE (23-901): 0: 791: 45.98		ITSN2_MOUSE (41-508): 1.34e-20: 97.9: 12.82
+	Hs
		1027627 CBLB_HUMAN (23-901): 0: 793: 46.65		ITSN2_HUMAN (44-508): 6.18e-18: 89.8: 11.98
+	Hs
		235501 CBLB_HUMAN (23-901): 0: 793: 46.65		VINEX_HUMAN (229-504): 5.02e-15: 79.8: 15.58
+	Hs
		1027634 CBLB_HUMAN (23-901): 0: 793: 46.65		CD2AP_HUMAN (451-508): 2.26e-14: 77.9: 40.68
+	Hs
		1027606 CBLB_HUMAN (23-901): 0: 793: 46.65		ITSN1_HUMAN (399-504): 1.82e-09: 62.5: 20.35
+	Hs
		1027613 CBLB_HUMAN (23-901): 0: 793: 46.65		SH3R1_HUMAN (244-503): 3.15e-09: 61.6: 17.28
+	Dm
		112567 O46034_DROME (47-460): 0: 746: 70.84		M9ND00_DROME (436-503): 4.72e-10: 64.4: 30.00