HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: UB2L3 (P68036)
Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3)
Gene: UBE2L3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.957

Property	Details
Experiments	10531381, 12234920, 18996392, 16735510, 29643511, 10966114, 15062086
Identification Methods	pull down, affinity chromatography technology, x-ray crystallography
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Cbl_N~UQ_con, UBA~UQ_con, UQ_con~zf-C3HC4
Common GO terms	GO:0000209 - protein polyubiquitination GO:0004842 - ubiquitin-protein transferase activity GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 154
+	Hs
		610305 CBL_HUMAN (1-906): 0: 917: 100.00		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		610333 CBL_HUMAN (1-906): 0: 917: 100.00		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		610323 CBL_HUMAN (1-906): 0: 917: 100.00		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		610469 CBL_HUMAN (1-906): 0: 917: 100.00		UB2E3_HUMAN (2-149): 2.39e-68: 207: 34.90
+	Hs
		610481 CBL_HUMAN (1-906): 0: 917: 100.00		UB2E2_HUMAN (2-149): 1.55e-68: 207: 34.90
+	Hs
		610307 CBL_HUMAN (1-906): 0: 917: 100.00		UB2E1_HUMAN (2-149): 6.55e-67: 203: 34.90
+	Hs
		919717 CBLB_HUMAN (23-901): 0: 793: 46.65		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Mm
		895981 CBLB_MOUSE (23-901): 0: 791: 45.98		UB2D1_MOUSE (2-149): 5.66e-75: 221: 38.26
+	Hs
		932508 CBLB_HUMAN (23-901): 0: 793: 46.65		UB2L3_HUMAN (1-154): 1.26e-64: 196: 100.00
+	Hs
		849487 CBLC_HUMAN (42-504): 0: 620: 42.07		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		919905 CBLC_HUMAN (42-504): 0: 620: 42.07		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		895953 CBLC_HUMAN (42-504): 0: 620: 42.07		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		932597 CBLC_HUMAN (42-504): 0: 620: 42.07		UB2L3_HUMAN (1-154): 1.26e-64: 196: 100.00
+	Hs
		159103 CBLC_HUMAN (42-504): 0: 620: 42.07		UB2L6_HUMAN (1-152): 4e-53: 166: 55.26