HitPredict

Interactor 1: COF1 (P23528)
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Gene: CFL1

Interactor 2: ACTH (P63267)
Actin, gamma-enteric smooth muscle (EC 3.6.4.-) (Alpha-actin-3) (Gamma-2-actin) (Smooth muscle gamma-actin) [Cleaved into: Actin, gamma-enteric smooth muscle, intermediate form]
Gene: ACTG2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37071682
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005615 - extracellular space GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0030027 - lamellipodium GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 166 Hs			1 376
+	Hs
		618104 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTBL_HUMAN (1-376): 0: 713: 87.77
+	Mm
		578583 COF1_MOUSE (1-166): 1.35e-72: 217: 98.80		ACTB_MOUSE (1-376): 0: 601: 93.35
+	Rn
		799735 COF1_RAT (1-166): 3.11e-72: 216: 99.40		ACTB_RAT (1-376): 0: 601: 93.35
+	Hs
		618038 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTB_HUMAN (1-376): 0: 601: 93.35
+	Hs
		618049 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTG_HUMAN (3-376): 0: 601: 94.39
+	Hs
		618096 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		Q1KLZ0_HUMAN (1-376): 0: 601: 93.35
+	Hs
		1092828 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		Q1KLZ0_HUMAN (1-376): 0: 601: 93.35
+	Hs
		891817 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTB_HUMAN (1-376): 0: 601: 93.35
+	Hs
		892124 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTB_HUMAN (1-376): 0: 601: 93.35
+	Hs
		929891 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTG_HUMAN (3-376): 0: 601: 94.39
+	Hs
		930059 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTG_HUMAN (3-376): 0: 601: 94.39
+	Hs
		618052 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTC_HUMAN (2-376): 0: 598: 98.67
+	Hs
		618053 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTS_HUMAN (2-376): 0: 598: 98.13
+	Hs
		932464 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		ACTC_HUMAN (2-376): 0: 598: 98.67
+	Hs
		618046 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		ACTA_HUMAN (1-376): 0: 595: 99.20
+	Hs
		891649 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		ACTB_HUMAN (1-376): 0: 601: 93.35
+	Hs
		894652 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		ACTG_HUMAN (3-376): 0: 601: 94.39
+	Hs
		894665 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		Q1KLZ0_HUMAN (1-376): 0: 601: 93.35
+	Hs
		894651 DEST_HUMAN (1-166): 3.71e-69: 208: 71.08		ACTA_HUMAN (1-376): 0: 595: 99.20
+	Sp
		501582 COFI_SCHPO (3-151): 4.28e-46: 149: 33.56		ACT_SCHPO (3-376): 0: 592: 89.04