HitPredict

Interactor 1: COF1 (P23528)
Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
Gene: CFL1

Interactor 2: CAP1 (Q01518)
Adenylyl cyclase-associated protein 1 (CAP 1)
Gene: CAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	33961781, 26186194, 28514442, 11950878
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005925 - focal adhesion GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 166 Hs			1 475
+	Hs
		618009 COF1_HUMAN (1-166): 4.46e-72: 215: 100.00		CAP2_HUMAN (1-473): 0: 647: 63.05
+	Hs
		768477 Q549N0_HUMAN (1-166): 1.68e-71: 214: 80.72		CAP2_HUMAN (1-473): 0: 647: 63.05
+	Hs
		768490 COF2_HUMAN (1-166): 1.68e-71: 214: 80.72		CAP2_HUMAN (1-473): 0: 647: 63.05
+	Hs
		965184 TWF1_HUMAN (3-157): 1.01e-34: 126: 21.52		CAP1_HUMAN (1-475): 0: 711: 100.00
+	Hs
		965198 TWF2_HUMAN (3-151): 2.29e-29: 111: 17.11		CAP1_HUMAN (1-475): 0: 711: 100.00
+	Hs
		768472 TWF1_HUMAN (3-157): 1.01e-34: 126: 21.52		CAP2_HUMAN (1-473): 0: 647: 63.05
+	Hs
		768480 TWF2_HUMAN (3-151): 2.29e-29: 111: 17.11		CAP2_HUMAN (1-473): 0: 647: 63.05
+	Sc
		568342 COFI_YEAST (3-150): 3.71e-44: 144: 36.67		CAP_YEAST (3-475): 5.74e-178: 510: 32.56
+	Sp
		737042 COFI_SCHPO (3-151): 4.28e-46: 149: 33.56		CAP_SCHPO (14-473): 8.25e-175: 503: 32.92