HitPredict

Interactor 1: UBC2 (P23566)
Ubiquitin-conjugating enzyme E2 2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 2) (RAD6 homolog) (Ubiquitin carrier protein 2) (Ubiquitin-protein ligase 2)
Gene: rhp6

Interactor 2: BRL1 (Q1MTQ0)
E3 ubiquitin-protein ligase brl1 (EC 2.3.2.27) (BRE1-like protein 1) (RING finger protein 2) (RING-type E3 ubiquitin transferase brl1)
Gene: BRL1

Species: Schizosaccharomyces pombe 972h-

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	17374714, 17363370
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	UQ_con~zf-C3HC4
Common GO terms	GO:0005634 - nucleus GO:0033503 - HULC complex GO:0040029 - epigenetic regulation of gene expression GO:0140673 - transcription elongation-coupled chromatin remodeling
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 151 Sp			1 692
+	Hs
		256237 UB2D2_HUMAN (5-149): 5.73e-81: 236: 39.31		BRE1B_HUMAN (336-692): 4.99e-36: 147: 19.78
+	Hs
		919748 UB2D2_HUMAN (5-149): 5.73e-81: 236: 39.31		BRE1A_HUMAN (54-692): 2.9e-35: 145: 13.61
+	At
		639386 UBC1_ARATH (1-151): 5.14e-76: 224: 70.86		BRE1A_ARATH (82-692): 8.9e-39: 156: 15.22
+	At
		790156 UBC2_ARATH (1-151): 4.97e-76: 224: 70.86		BRE1A_ARATH (82-692): 8.9e-39: 156: 15.22
+	At
		639387 UBC1_ARATH (1-151): 5.14e-76: 224: 70.86		BRE1B_ARATH (43-692): 4.09e-36: 148: 12.89
+	At
		790157 UBC2_ARATH (1-151): 4.97e-76: 224: 70.86		BRE1B_ARATH (43-692): 4.09e-36: 148: 12.89
+	Ce
		712245 UBC2_CAEEL (5-149): 1.06e-80: 236: 37.93		BRE1_CAEEL (169-692): 4.71e-32: 135: 15.14
+	Hs
		256227 UBE2A_HUMAN (1-149): 1.14e-75: 223: 72.48		BRE1B_HUMAN (336-692): 4.99e-36: 147: 19.78
+	Hs
		256229 UB2E1_HUMAN (3-150): 1.15e-74: 222: 35.14		BRE1B_HUMAN (336-692): 4.99e-36: 147: 19.78
+	Hs
		256239 UBE2B_HUMAN (1-149): 6.32e-75: 221: 71.81		BRE1B_HUMAN (336-692): 4.99e-36: 147: 19.78
+	Hs
		829017 UBE2A_HUMAN (1-149): 1.14e-75: 223: 72.48		BRE1A_HUMAN (54-692): 2.9e-35: 145: 13.61
+	Hs
		851821 UB2E1_HUMAN (3-150): 1.15e-74: 222: 35.14		BRE1A_HUMAN (54-692): 2.9e-35: 145: 13.61
+	Hs
		927757 UBE2B_HUMAN (1-149): 6.32e-75: 221: 71.81		BRE1A_HUMAN (54-692): 2.9e-35: 145: 13.61
+	Ce
		712246 UBC1_CAEEL (1-149): 1.4e-74: 222: 70.47		BRE1_CAEEL (169-692): 4.71e-32: 135: 15.14
+	Sc
		410240 UBC2_YEAST (1-150): 1.4e-73: 219: 77.33		BRE1_YEAST (140-692): 7.21e-30: 127: 19.68
+	Sp
		251716 UBC2_SCHPO (1-151): 5.42e-74: 219: 100.00		BRL2_SCHPO (216-692): 2.63e-28: 122: 17.71